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Patent Searching and Data


Title:
MASSIVELY PARALLEL COMBINATORIAL GENETICS FOR CRISPR
Document Type and Number:
WIPO Patent Application WO/2016/070037
Kind Code:
A8
Abstract:
Described herein are methods and compositions that enable rapid generation of high-order combinations of genetic elements comprising a CRISPR guide sequence and a scaffold sequence, and a barcode for rapid identification of the combination of genetic elements encoded within a single cell or a pooled population. Also described herein compositions of inhibitors of epigenetic genes and methods for reducing cell proliferation and/or treating cancer.

Inventors:
LU TIMOTHY KUAN-TA (US)
WONG ALAN SIU LUN (US)
CHOI CHING GEE (US)
Application Number:
PCT/US2015/058304
Publication Date:
March 02, 2017
Filing Date:
October 30, 2015
Export Citation:
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Assignee:
MASSACHUSETTS INST TECHNOLOGY (US)
International Classes:
C12N15/10
Attorney, Agent or Firm:
DIPIETRANTONIO, Heather, J. (Greenfield & Sacks P.C.,600 Atlantic Avenu, Boston MA, US)
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