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Title:
MATERIALS AND METHODS USEFUL TO TREAT NEUROBLASTOMAS AND PHEOCHROMOCYTOMAS
Document Type and Number:
WIPO Patent Application WO/2014/059279
Kind Code:
A3
Abstract:
Methods for affecting one or more of: proliferation, migration and invasion of tumor cells are described. One method includes contacting the tumor cell with an effective amount of a composition such as tianeptine. Described herein are results showing that tianeptine causes apoptosis by increasing microtubule bundling in neuroblastoma and pheochromocytoma cells. In addition, tianeptine blocks growth of neuroblastoma and pheochromocytoma by inducing specific and rapid degradation of cytoplasmic dynein, a microtubule motor protein that arranges the mitotic spindles during mitosis.

Inventors:
PARK JOSHUA J (US)
HENSLEY KENNETH (US)
Application Number:
PCT/US2013/064546
Publication Date:
June 05, 2014
Filing Date:
October 11, 2013
Export Citation:
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Assignee:
UNIV TOLEDO (US)
International Classes:
A61K31/00
Domestic Patent References:
WO2012109705A12012-08-23
WO2009101012A12009-08-20
Foreign References:
US20060276527A12006-12-07
US20050031648A12005-02-10
US20110117627A12011-05-19
Other References:
"Annual Report on Technology Transfer", ADVANCING INNOVATION AND ENTREPRENEURSHIP, 2011, UNIVERSITY OF TOLEDO, pages 1 - 4
LI ET AL.: "Induction of apoptosis in pheochromocytoma (PC12) cells exposed to eicosapentaenoic acid in vitro.", INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS, vol. 42, August 2005 (2005-08-01), pages 222 - 229
MATERIALS AND METHODS FOR TREATING NEUROBLASTOMA AND MALIGNANT PHEOCHROM., 23 October 2012 (2012-10-23), UNIVERSITY OF TOLEDO, pages 1 - 2
Attorney, Agent or Firm:
MARTINEAU, Catherine, B. (Sobanski & Todd LLC, One Maritime Plaza, US)
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