Title:
MEDICAMENT FOR EFFICIENTLY KILLING DRUG-RESISTANT DISEASE BACTERIA AND APPLICATION THEREOF IN INHIBITING DRUG-RESISTANT DISEASE BACTERIA
Document Type and Number:
WIPO Patent Application WO/2021/073131
Kind Code:
A1
Abstract:
Provided in the present invention are a medicament for effectively killing drug-resistant disease bacteria and an application thereof in inhibiting drug-resistant disease bacteria. Specifically, provided in the present invention is a composition for killing or inhibiting disease bacteria, which comprises an active combination that consists of a first active ingredient TPAD and a second active ingredient QseC/B signaling pathway inhibitor.
Inventors:
YU RILEI (CN)
WANG YAN (CN)
WANG YAN (CN)
Application Number:
PCT/CN2020/095683
Publication Date:
April 22, 2021
Filing Date:
June 11, 2020
Export Citation:
Assignee:
OCEAN UNIV CHINA (CN)
International Classes:
A61K31/18; A61K38/10; A61P31/04; C07C335/16
Domestic Patent References:
| WO2009088549A2 | 2009-07-16 | |||
| WO2018140479A1 | 2018-08-02 | |||
| WO2018140518A1 | 2018-08-02 | |||
| WO2018023021A1 | 2018-02-01 |
Foreign References:
| CN108623659A | 2018-10-09 | |||
| CN101857562A | 2010-10-13 | |||
| CN110680904A | 2020-01-14 |
Other References:
MEREDITH M. CURTIS ET AL.: "QseC inhibitors as an antivirulence approach for Gram-negative pathogens", MBIO., vol. 5, no. 6, 11 November 2014 (2014-11-11), pages 1 - 11, XP055802845
YU RILEI, WANG JIAYI, SO LOK-YAN, HARVEY PETA J., SHI JUAN, LIANG JIAZHEN, DOU QIN, LI XIAO, YAN XIAYI, HUANG YEN-HUA, XU QINGLIAN: "Enhanced Activity against Multidrug-Resistant Bacteria through Coapplication of an Analogue of Tachyplesin I and an Inhibitor of the QseC/B Signaling Pathway", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 63, no. 7, 9 April 2020 (2020-04-09), US, pages 3475 - 3484, XP055802851, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.9b01563
YU RILEI, WANG JIAYI, SO LOK-YAN, HARVEY PETA J., SHI JUAN, LIANG JIAZHEN, DOU QIN, LI XIAO, YAN XIAYI, HUANG YEN-HUA, XU QINGLIAN: "Enhanced Activity against Multidrug-Resistant Bacteria through Coapplication of an Analogue of Tachyplesin I and an Inhibitor of the QseC/B Signaling Pathway", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 63, no. 7, 9 April 2020 (2020-04-09), US, pages 3475 - 3484, XP055802851, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.9b01563
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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