Title:
MEDICINAL COMPOSITION FOR BONE RESORPTION INHIBITION AND OSTEOGENESIS ACCELERATION
Document Type and Number:
WIPO Patent Application WO/1995/018141
Kind Code:
A1
Abstract:
A medicinal composition containing a compound represented by the general formula (I): X-Y-Z (wherein Y represents a group represented by any of general formulae (III) to (V), X represents a monovalent radical derived from a tetracycline compound; and Z represents a monovalent radical derived from a steroid compound such as estrogen), which can be intensively administered to bony tissues and has the effects of inhibiting bone resorption and accelerating osteogenesis.
Inventors:
ZHENG HU (CN)
WENG LINGLING (CN)
WENG LINGLING (CN)
Application Number:
PCT/JP1994/002303
Publication Date:
July 06, 1995
Filing Date:
December 28, 1994
Export Citation:
Assignee:
ISKRA INDUSTRY CO LTD (JP)
INST OF PHARMACOLOGY (CN)
ZHENG HU (CN)
WENG LINGLING (CN)
INST OF PHARMACOLOGY (CN)
ZHENG HU (CN)
WENG LINGLING (CN)
International Classes:
A61K31/565; A61K31/57; A61K31/65; A61P3/00; A61P19/10; A61P33/00; A61P43/00; C07J41/00; C07J43/00; C07J71/00; (IPC1-7): C07J41/00; A61K31/65; C07J43/00
Domestic Patent References:
| WO1994021667A1 | 1994-09-29 |
Foreign References:
| JPH04352795A | 1992-12-07 | |||
| JPS6226256A | 1987-02-04 | |||
| JPH0236145A | 1990-02-06 | |||
| DE3907290A1 | 1990-09-13 | |||
| GB2201419A | 1988-09-01 | |||
| DE2932606A1 | 1980-02-28 |
Other References:
Bioorg. Med. Chem. Lett., Vol. 4, No. 11 (1994), p. 1375-1380, ORME, MARK W., "Synthesis of Beta-Estradiol-3-Benzoate-17-(Succinyl-12A- Tetracycline): a Potential Bone-Seeking Estrogen".
See also references of EP 0688787A4
See also references of EP 0688787A4
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