Title:
MEDICINAL COMPOSITION FOR TREATING DISEASES ASSOCIATED WITH INCREASE IN EXPRESSION LEVEL OF PERIOSTIN OR CHANGE IN SPLICING VARIANT THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/146621
Kind Code:
A1
Abstract:
Provided is a medicinal composition for treating diseases associated with an increase in the expression level of periostin or a change in a periostin splicing variant, said medicinal composition being characterized by comprising, as an active ingredient, a nucleic acid by which exon 17 is skipped in the transcription step of periostin gene and/or a nucleic acid by which exon 21 is skipped therein. Using the medicinal composition according to the present invention, it is possible to treat diseases associated with an increase in the expression level of periostin or a change in a periostin splicing variant without completely inhibiting the function of periostin.
Inventors:
SANADA FUMIHIRO (JP)
TANIYAMA YOSHIAKI (JP)
MORISHITA RYUICHI (JP)
TANIYAMA YOSHIAKI (JP)
MORISHITA RYUICHI (JP)
Application Number:
PCT/JP2019/002015
Publication Date:
August 01, 2019
Filing Date:
January 23, 2019
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
A61K31/711; A61K35/76; A61K48/00; A61P9/04; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P19/02; A61P27/02; A61P29/00; A61P35/00; A61P35/04; A61P37/08; A61P43/00
Domestic Patent References:
| WO2009001940A1 | 2008-12-31 | |||
| WO2014136910A1 | 2014-09-12 | |||
| WO2012168435A1 | 2012-12-13 | |||
| WO2013053819A1 | 2013-04-18 | |||
| WO2016142538A1 | 2016-09-15 | |||
| WO2017098187A1 | 2017-06-15 | |||
| WO2002020055A1 | 2002-03-14 |
Other References:
AARTSMA-RUS, ANNEMIEKE ET AL.: "Antisense-mediated exon skipping: A versatile tool with therapeutic and research applications", RNA, vol. 13, no. 10, October 2007 (2007-10-01), pages 1609 - 1624, XP009144451, ISSN: 1355-8382
TANIYAMA, YOSHIAKI ET AL.: "Selective Blockade of Periostin Exon 17 Preserves Cardiac Performance in Acute myocardial Infarction", HYPERTENTION, vol. 67, no. 2, February 2016 (2016-02-01), pages 356 - 361, XP055630100, ISSN: 0194-911X
TANIYAMA, YOSHIAKI ET AL.: "Selective Blockade of Periostin Exon 17 Preserves Cardiac Performance in Acute myocardial Infarction", HYPERTENTION, vol. 67, no. 2, February 2016 (2016-02-01), pages 356 - 361, XP055630100, ISSN: 0194-911X
Attorney, Agent or Firm:
IWATANI, Ryo (JP)
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