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Patent Searching and Data


Title:
MEMBRANE-BASED ASSAYS
Document Type and Number:
WIPO Patent Application WO2004025262
Kind Code:
A3
Abstract:
Membrane-based assays using surface detector array devices suitable for use with a biosensor are disclosed. The device is formed of a substrate having a surface defining a plurality of distinct bilayer-compatible surface regions separated by one or more bilayer barrier regions. The bilayer-compatible surface regions carry on them, separated by an aqueous film, supported fluid bilayers. The bilayers may contain selected receptors or biomolecules. A bulk aqueous phase covers the bilayers on the substrate surface. Arrays may be engineered to display natural membrane materials in a native fluid bilayer configuration, permitting high-throughput discovery of drugs that target and affect membrane components. The membrane-based assays detect binding events by monitoring binding-induced changes in one or more physical properties of fluid bilayers.

Inventors:
YAMAZAKI VIKKY
SCHAFER ROBERT J
ULMAN MORRISON
GROVES JOHN T
Application Number:
US0328762W
Publication Date:
June 17, 2004
Filing Date:
September 11, 2003
Export Citation:
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Assignee:
SYNAMEM CORP (US)
International Classes:
G01N24/10; C12Q1/18; C40B30/04; G01N13/10; G01N13/16; G01N13/24; G01N21/78; G01N27/02; G01N27/447; G01N33/15; G01N33/483; G01N33/50; G01N33/543; G01N33/566; G01N33/68; G01N37/00; (IPC1-7): G01N27/12; G01N27/26; G01N33/53; G01N33/543
Domestic Patent References:
WO1998023948A11998-06-04
Foreign References:
US5846814A1998-12-08
US5204239A1993-04-20
US5798030A1998-08-25
US6228326B12001-05-08
Other References:
See also references of EP 1546696A4
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