Title:
MEMBRANE-PERMEABLE MOLECULE AND USE THEREFOR, AND METHOD FOR IMPROVING MEMBRANE PERMEABILITY OF MEMBRANE-PERMEABLE MOLECULE
Document Type and Number:
WIPO Patent Application WO/2022/065173
Kind Code:
A1
Abstract:
Provided are: a membrane-permeable molecule which has a structure represented by general formula (i) and forms a salt with an acid having a pKa value greater than -8.0 and less than 4.7; and a method for improving the membrane permeability of a membrane-permeable molecule which involves forming the membrane-permeable molecule, which has a structure represented by general formula (i), as a salt with an acid having a pKa value greater than -8.0.
Inventors:
KOMIYA CHIAKI (JP)
SHIKAKURA TOSHIHIRO (JP)
IGUCHI KEITA (JP)
HIRAYAMA YUSUKE (JP)
FUJII TOSHIHIDE (JP)
KITANO MITSUAKI (JP)
MOUTAI TATSUYA (JP)
KITA HIROSHI (JP)
SHIKAKURA TOSHIHIRO (JP)
IGUCHI KEITA (JP)
HIRAYAMA YUSUKE (JP)
FUJII TOSHIHIDE (JP)
KITANO MITSUAKI (JP)
MOUTAI TATSUYA (JP)
KITA HIROSHI (JP)
Application Number:
PCT/JP2021/034021
Publication Date:
March 31, 2022
Filing Date:
September 16, 2021
Export Citation:
Assignee:
KANEKA CORP (JP)
International Classes:
C07K2/00; A61K38/02; A61K38/04; A61K38/12; A61K47/16; A61K47/18; A61K47/22; A61K47/54; A61K47/60; A61K47/64; C40B40/10; G01N33/15
Domestic Patent References:
| WO2019213662A1 | 2019-11-07 | |||
| WO2020195303A1 | 2020-10-01 | |||
| WO2020195302A1 | 2020-10-01 |
Foreign References:
| US7862807B2 | 2011-01-04 | |||
| JP2020502051A | 2020-01-23 | |||
| US20080221043A1 | 2008-09-11 |
Attorney, Agent or Firm:
HIROTA, Koichi et al. (JP)
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