Title:
MEMBRANE PERMEATION ENHANCER AND METHOD FOR ENHANCING MEMBRANE PERMEATION
Document Type and Number:
WIPO Patent Application WO/2021/054351
Kind Code:
A1
Abstract:
Provided are: a novel membrane permeation enhancer which contains an amino acid-based surfactant and exhibits excellent safety; and a method for enhancing membrane permeation using this membrane permeation enhancer. The amino acid-based surfactant may be a compound represented by formula (1) or a salt thereof. In the formula, R1 denotes a hydrogen atom or a monovalent organic group, R2 denotes a hydrogen atom, -R4, -COR4 or -CH2CH(OH)R4, and R3 denotes -OH, -OR5, -NHR5 or -O(R6O)nH. One of R4 and R5 denotes an aliphatic hydrocarbon group having 6-20 carbon atoms, and the other denotes a hydrocarbon group which has 1-20 carbon atoms and which may include a hetero-atom. R6 denotes an alkylene group having 2-4 carbon atoms, and n denotes a number between 1 and 50. However, a case where R2 is a hydrogen atom and R3 is -OH or -O(R6O)nH is excluded.
Inventors:
SAKAI HIDEKI (JP)
SAKAMOTO KAZUTAMI (JP)
TANAKA KAZUKI (JP)
YOKOYAMA KIICHI (JP)
KITANO TAKESHI (JP)
SAKAMOTO KAZUTAMI (JP)
TANAKA KAZUKI (JP)
YOKOYAMA KIICHI (JP)
KITANO TAKESHI (JP)
Application Number:
PCT/JP2020/035047
Publication Date:
March 25, 2021
Filing Date:
September 16, 2020
Export Citation:
Assignee:
UNIV TOKYO SCIENCE FOUND (JP)
International Classes:
C07C279/14; A61K47/18
Foreign References:
| JP2005154413A | 2005-06-16 |
Other References:
TANAKA, KATSUKI: "Effect of Amino-Acid-Based Surfacants on Physical Properties of Lipid Bimolecular Membranes", ABSTRACTS OF THE 57TH ANNUAL MEETING OF THE JAPAN OIL CHEMISTS' SOCIETY, 4 September 2018 (2018-09-04), pages 203
SAKAMOTO KAZUTAMI, ABURAI KENICHI, MORISHITA TAKU, SAKAI KENICHI, SAKAI HIDEKI, ABE MASAHIKO, NAKASE IKUHIKO, FUTAKI SHIROH: "Bioinspired Mechanism for the Translocation of Peptide through the Cell Membrane", CHEMISTRY LETTERS, vol. 41, no. 10, 2012, pages 1078 - 1080, XP055807597
MÓNICA ROSA, MARIA ROSA INFANTE, MARIA DA G. MIGUEL, AND BJÖRN LINDMAN: "Spontaneous Formation of Vesicles and Dispersed Cubic and Hexagonal Particles in Amino Acid-Based Catanionic Surfactant Systems", LANGMUIR, vol. 22, 2006, pages 5588 - 5596, XP055807606
SAKAMOTO KAZUTAMI, ABURAI KENICHI, MORISHITA TAKU, SAKAI KENICHI, SAKAI HIDEKI, ABE MASAHIKO, NAKASE IKUHIKO, FUTAKI SHIROH: "Bioinspired Mechanism for the Translocation of Peptide through the Cell Membrane", CHEMISTRY LETTERS, vol. 41, no. 10, 2012, pages 1078 - 1080, XP055807597
MÓNICA ROSA, MARIA ROSA INFANTE, MARIA DA G. MIGUEL, AND BJÖRN LINDMAN: "Spontaneous Formation of Vesicles and Dispersed Cubic and Hexagonal Particles in Amino Acid-Based Catanionic Surfactant Systems", LANGMUIR, vol. 22, 2006, pages 5588 - 5596, XP055807606
Attorney, Agent or Firm:
SHOBAYASHI Masayuki et al. (JP)
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