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Patent Searching and Data


Title:
METABOLITE AT POSITION 21 OF FENLEAN, AND PREPARATION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/244635
Kind Code:
A1
Abstract:
Provided in the present invention are a metabolite at position 21 of Fenlean, and the preparation and the use thereof. The metabolite at position 21 of Fenlean of the present invention has a good antioxidant activity and anti-neuroinflammatory and neuroprotective activities. The metabolite at position 21 of Fenlean is as represented by the following formula (I): (I)

Inventors:
JIA ZHENHUA (CN)
WU XIANGJUN (CN)
YANG QINGRUI (CN)
LIU RUI (CN)
WANG HONGTAO (CN)
Application Number:
PCT/CN2021/098309
Publication Date:
December 09, 2021
Filing Date:
June 04, 2021
Export Citation:
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Assignee:
SHIJIAZHUANG YILING PHARMACEUTICAL CO LTD (CN)
International Classes:
C07H15/203; C07D309/10
Foreign References:
CN1445211A2003-10-01
Other References:
WANG TENG, WANG HUANHUAN, CHEN RUI, JIANG, ZHAO QIAN, HU PEI: "A UHPLC-MS/MS method to determine FLZ major active metabolites in human plasma: application to a pharmacokinetic study", BIOANALYSIS, vol. 12, no. 9, 29 May 2020 (2020-05-29), pages 583 - 596, XP009532707, ISSN: 1757-6180, DOI: 10.4155/bio-2020-0033
HAYES JOHN A.; ECCLES KEVIN S.; LAWRENCE SIMON E.; MOYNIHAN HUMPHREY A.: "Preparation and characterisation of solid state forms of paracetamol-O-glucuronide", CARBOHYDRATE RESEARCH, PERGAMON, GB, vol. 349, 1 January 1900 (1900-01-01), GB , pages 108 - 112, XP028887775, ISSN: 0008-6215, DOI: 10.1016/j.carres.2011.12.018
KVAERNO L, ET AL: "An In Vitro Assay for Evaluation of Small-Molecule Inhibitors of Cholesterol Absorption", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, ┬ČVERLAG CHEMIE| :, vol. 43, 1 January 2004 (2004-01-01), pages 4653 - 4655, XP002362656, ISSN: 1433-7851, DOI: 10.1002/anie.200460348
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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