Title:
METFORMIN TAURATE, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND COMBINED FORMULATION COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2011/025269
Kind Code:
A2
Abstract:
The present invention relates to metformin taurate, to a method for preparing same, to a pharmaceutical composition comprising same, and to a combined formulation comprising same. The metformin taurate of the present invention has superior stability, enables easy tabletting, has low toxicity, and exhibits excellent AMPKα-activating effects, and thus can be effectively used in treating glycosuria, diabetes, metabolic syndrome, diabetes complications, menstrual irregularities, hypertension, hyperlipidemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndrome, cancer, myalgia, symptoms of muscle cell cytotoxicity, climacterium and rhabdomyolysis, etc., and provides antioxidant activity.
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Inventors:
KIM SUNG WUK (KR)
JUN SUNG SOO (KR)
MIN CHANGHEE (KR)
KOO JA SEONG (KR)
KANG MIN SEOK (KR)
KIM YONG EUN (KR)
JUN SUNG SOO (KR)
MIN CHANGHEE (KR)
KOO JA SEONG (KR)
KANG MIN SEOK (KR)
KIM YONG EUN (KR)
Application Number:
PCT/KR2010/005711
Publication Date:
March 03, 2011
Filing Date:
August 25, 2010
Export Citation:
Assignee:
HANALL BIOPHARMA CO LTD (KR)
KIM SUNG WUK (KR)
JUN SUNG SOO (KR)
MIN CHANGHEE (KR)
KOO JA SEONG (KR)
KANG MIN SEOK (KR)
KIM YONG EUN (KR)
KIM SUNG WUK (KR)
JUN SUNG SOO (KR)
MIN CHANGHEE (KR)
KOO JA SEONG (KR)
KANG MIN SEOK (KR)
KIM YONG EUN (KR)
International Classes:
C07C279/26; A61K31/145; A61K31/155; C07C309/14
Domestic Patent References:
| WO2008112167A1 | 2008-09-18 | |||
| WO2005092311A1 | 2005-10-06 |
Other References:
ERONS, C. ET AL.: 'Effect of taurine treatment on insulin secretion and action, and on serum lipid levels in overweight men with a genetic predisposition for type II diabetes mellitusEuropean' EUROPEAN JOURNAL OF CLINICAL NUTRITION vol. 58, 2004, pages 1239 - 1247
ZHANG, F-E ET AL.: 'Pharmacokinetics of single metformin hydrochloride and compound metformin-taurine capsules in beagle dogs' SHENYANG YAOKE DAXUE XUEBAO vol. 26, no. 9, 17 September 2009, pages 740 - 744
ZHANG, F-E ET AL.: 'Pharmacokinetics of single metformin hydrochloride and compound metformin-taurine capsules in beagle dogs' SHENYANG YAOKE DAXUE XUEBAO vol. 26, no. 9, 17 September 2009, pages 740 - 744
Attorney, Agent or Firm:
AHN, So-Young (KR)
안소영 (KR)
안소영 (KR)
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