Title:
METHOD FOR CHEMICAL SYNTHESIS OF OXCARBAZEPINE
Document Type and Number:
WIPO Patent Application WO/2010/000196
Kind Code:
A1
Abstract:
Method for chemical synthesis of oxcarbazepine comprises adding 5-cyano-11-nitro-5H dibenzoaza of formula III, Raney nickel catalyst, and organic solvent into a reactor, adding hydrogen at 2-20A, controlling the temperature to 40-120℃ and carrying out reduction reaction, filtering after reacting completely, hydrolyzing the filtrate by adding 20-36.5 mass % hydrochloric acid, concentrating and cooling crystallizing the reaction liquid, and obtaining the oxcarbazepine. The method has advantages of advanced process, simple and safe operation, and high product purity and yield, which is suitable for commercial production.
Inventors:
SU WEIKE (CN)
LI JIANJUN (CN)
JIANG ZULIN (CN)
XU JIANKANG (CN)
SONG GANG (CN)
LI JIANJUN (CN)
JIANG ZULIN (CN)
XU JIANKANG (CN)
SONG GANG (CN)
Application Number:
PCT/CN2009/072527
Publication Date:
January 07, 2010
Filing Date:
June 30, 2009
Export Citation:
Assignee:
UNIV ZHEJIANG TECHNOLOGY (CN)
ZHEJIANG JIUZHOU PHARMACEUTICA (CN)
SU WEIKE (CN)
LI JIANJUN (CN)
JIANG ZULIN (CN)
XU JIANKANG (CN)
SONG GANG (CN)
ZHEJIANG JIUZHOU PHARMACEUTICA (CN)
SU WEIKE (CN)
LI JIANJUN (CN)
JIANG ZULIN (CN)
XU JIANKANG (CN)
SONG GANG (CN)
International Classes:
C07D223/22; A61P25/08
Domestic Patent References:
| WO2005092862A1 | 2005-10-06 |
Foreign References:
| US4452738A | 1984-06-05 | |||
| US4436660A | 1984-03-13 | |||
| CN101314590A | 2008-12-03 | |||
| MU2004MU00663A | ||||
| JP2004175761A | 2004-06-24 |
Other References:
See also references of EP 2311812A4
Attorney, Agent or Firm:
TIANZHENG PATENT & TRADEMARK ATTORNEYS (Changdimingyuan No.9 Qingchun Roa, Hangzhou Zhejiang 9, CN)
Download PDF:
Previous Patent: LOCK DEVICE FOR SLIDING DOOR
Next Patent: A METHOD FOR PREPARING 5H-CYANO-IMIDO STILBENE
Next Patent: A METHOD FOR PREPARING 5H-CYANO-IMIDO STILBENE