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Title:
METHOD AND COMPOUND USEFUL IN PREPARATION OF OREXIN-2 RECEPTOR ANTAGONIST, AND LEMBOREXANT HAVING FEW IMPURITIES
Document Type and Number:
WIPO Patent Application WO/2020/230800
Kind Code:
A1
Abstract:
The present application discloses a method and a compound useful in the preparation of a compound represented by formula (XI). Furthermore, the present application discloses a compound that is represented by formula (XI) and that has few impurities.

Inventors:
ABE TAICHI (JP)
YOSHIZAWA KAZUHIRO (JP)
WATANABE YUZO (JP)
MIURA TAKESHI (JP)
AYATA YUSUKE (JP)
YASUDA YOSHINORI (JP)
Application Number:
JP2020/019037
Publication Date:
November 19, 2020
Filing Date:
May 13, 2020
Export Citation:
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Assignee:
EISAI R&D MAN CO LTD (JP)
International Classes:
C07C67/14; C07C29/147; C07C33/50; C07C69/63; C07C303/28; C07C309/73; C07D239/34; C07D401/12; A61K31/506; A61P25/20; A61P43/00; C07B61/00
Domestic Patent References:
WO2012039371A12012-03-29
WO2020050339A12020-03-12
Foreign References:
JP2015509939A2015-04-02
US20120165339A12012-06-28
US20200190060A12020-06-18
Other References:
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WUTS, P. G. M., GREENE'S PROTECTIVE GROUPS IN ORGANIC SYNTHESIS, 2014, pages 271 - 283
OISHI, TAKASHI: "Protective Group in Organic Synthesis -Protection of Hydroxyl Group", JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY, vol. 36, no. 9, 1978, Japan, pages 715 - 722, XP009524646, DOI: 10.5059/yukigoseikyokaishi.36.715
SEKI, M. ET AL.: "Synthesis of (2S, 3R, 11S, 12R, 2"'R, 11"'S, 12"'R)-plakoside A, a prenylated and immunosuppressive marine galactosphingolipid with cyclopropane-containing alkyl chains", TETRAHEDRON LETTERS, vol. 42, 2001, pages 2357 - 2360, XP004229922, DOI: 10.1016/S0040-4039(01)00175-7
FRESSIGNE, C. ET AL.: "A C3' modified nucleotide. The difluorophosphonate function, a phosphate mimic, governs the conformational behaviour of the ribofuranose", TETRAHEDRON, vol. 61, 2005, pages 4769 - 4777, XP025384232, DOI: 10.1016/j.tet.2005.03.028
NIGGEMANN, M ET AL.: "A General, Iterative, and Modular Approach toward Carbohydrate Libraries Based on Ruthenium-Catalyzed Oxidative Cyclizations", J. ORG. CHEM., vol. 73, 2008, pages 7028 - 7036, XP055760637
STOLLE, A. ET AL.: "Palladium(O) catalyzed substitution reactions of cyclopropyl group containing allylic esters", TETRAHEDRON LETTERS, vol. 31, no. 32, 1990, pages 4593 - 4596, XP026648990, DOI: 10.1016/S0040-4039(00)97684-6
YOSHIDA, Y. ET AL.: "Design, synthesis, and structure-activity relationships of a series of novel N-aryl-2-phenylcyclopropanecarboxamide that are potent and orally active orexin receptor antagonists", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 22, no. 21, 2014, pages 6071 - 6088, XP055760640
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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