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Title:
METHOD FOR CONTINUOUS SYNTHESIS OF SUBSTITUTED BENZOIC-ACID ORGANIC SUBSTANCE
Document Type and Number:
WIPO Patent Application WO/2020/248278
Kind Code:
A1
Abstract:
The present invention provides a method for the continuous synthesis of a substituted benzoic-acid organic substance. The continuous synthesis method comprises: in the presence of catalyst and organic solvent, the organic matter represented by formula (I) and oxygen are continuously inputted to a continuous reaction apparatus for continuous oxidation reaction to obtain a substituted benzoic-acid organic substance, which is discharged continuously, the substituted benzoic-acid organic substance having the structure represented by formula (II). Oxygen is a green reagent and is inexpensive and readily available; a large amount of wastewater, waste gas, and solid waste is not generated after the reaction, and the system is easy to handle. The use of a continuous reaction operation can reduce the risk of flash distillation and explosion of solvent due to a high concentration of oxygen in a batch reaction. Under the same oxidation conditions, the continuous preparation process can reduce the escape of oxygen, greatly increasing the oxygen utilization rate and also simplifying the operation, improving the safety of the reaction and the yield of the substituted benzoic-acid organic substance.

Inventors:
HONG HAO (US)
ZHANG ENXUAN (CN)
LU JIANGPING (CN)
LIU ZHIQING (CN)
LI CHAO (CN)
TANG YANG (CN)
Application Number:
PCT/CN2019/091400
Publication Date:
December 17, 2020
Filing Date:
June 14, 2019
Export Citation:
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Assignee:
JINLIN ASYMCHEM LABORATORIES CO LTD (CN)
International Classes:
C07C51/245; C07C63/68; C07C63/70; C07C201/12; C07C205/58; C07C205/59
Foreign References:
CN108911944A2018-11-30
CN109503540A2019-03-22
CN109053347A2018-12-21
CN108002968A2018-05-08
JPH04159247A1992-06-02
US4423245A1983-12-27
CN103304422A2013-09-18
Attorney, Agent or Firm:
KANGXIN PARTNERS,P.C. (CN)
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