Title:
METHOD FOR COUPLING ORGANIC COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2019/225742
Kind Code:
A1
Abstract:
Constructed is a technology capable of coupling organic compounds efficiently, inexpensively, simply, and in a short time by a small number of steps. A method for coupling organic compounds, wherein the method for coupling organic compounds has a step for: reacting, in a reaction solvent, an organic halide and a dispersion in which sodium is dispersed in a dispersion solvent to obtain an organic sodium compound; and reacting the resulting organic sodium compound and an organic chloride in the presence of a reaction catalyst including a palladium catalyst that has a nitrogen-containing heterocyclic carbene (NHC) ligand to obtain a coupling product.
Inventors:
MURAKAMI YOSHIAKI (JP)
FUKUSHIMA MIYUKI (JP)
TAKAI KAZUHIKO (JP)
ASAKO SOBI (JP)
FUKUSHIMA MIYUKI (JP)
TAKAI KAZUHIKO (JP)
ASAKO SOBI (JP)
Application Number:
PCT/JP2019/020669
Publication Date:
November 28, 2019
Filing Date:
May 24, 2019
Export Citation:
Assignee:
KOBELCO ECO SOLUTIONS CO LTD (JP)
NAT UNIV CORPORATION OKAYAMA UNIV (JP)
NAT UNIV CORPORATION OKAYAMA UNIV (JP)
International Classes:
C07B37/04; C07C1/32; C07C15/24; C07C41/30; C07C43/205; C07C209/68; C07C211/48; C07D217/14; C07D307/79; C07B61/00
Domestic Patent References:
| WO2017208970A1 | 2017-12-07 |
Foreign References:
| US20070073055A1 | 2007-03-29 |
Other References:
BIELINSKI, ELIZABETH A. ET AL.: "Synthesis, properties, and reactivity of palladium and nickel NHC complexes supported by combinations of allyl, cyclopentadienyl, and indenyl ligands", ORGANOMETALLICS, vol. 32, no. 15, 10 May 2013 (2013-05-10), pages 4025 - 4037, XP055655803, ISSN: 0276-7333, DOI: 10.1021/om4002632
NAKASHIMA , HIROKI ET AL: "Preparation of aryl sodium compounds from aryl chlorides having sodium dispersion and application to cross-coupling reactions(non official translation)", LECTURE PREPRINTS OF THE 98TH SPRING ANNUAL MEETING, 6 March 2018 (2018-03-06)
ASAKO, SOBI ET AL.: "Organosodium compounds for catalytic cross-coupling", NATURE CATALYSIS, vol. 2, no. 4, 18 March 2019 (2019-03-18), pages 297 - 303, XP055655796, DOI: 10.1038/s41929-019-0250-6
NAKASHIMA , HIROKI ET AL: "Preparation of aryl sodium compounds from aryl chlorides having sodium dispersion and application to cross-coupling reactions(non official translation)", LECTURE PREPRINTS OF THE 98TH SPRING ANNUAL MEETING, 6 March 2018 (2018-03-06)
ASAKO, SOBI ET AL.: "Organosodium compounds for catalytic cross-coupling", NATURE CATALYSIS, vol. 2, no. 4, 18 March 2019 (2019-03-18), pages 297 - 303, XP055655796, DOI: 10.1038/s41929-019-0250-6
Attorney, Agent or Firm:
R&C IP LAW FIRM (JP)
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