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Patent Searching and Data


Title:
METHOD OF DESIGNING TUBULIN POLYMERIZATION STABILIZERS
Document Type and Number:
WIPO Patent Application WO2001005779
Kind Code:
A3
Abstract:
A method for designing paclitaxel alternative compounds which stabilize the tubulin polymerization process has been found. These compounds in solution possess steric conformational properties of natural paclitaxel and are capable of binding to the tubulin protein at the same site where paclitaxel is known to bind. The compounds of the present invention stabilize tubulin polymerization in a way that is mechanistically equivalent to activity mechanism of paclitaxel. The compounds of the present invention have increased solubility, simpler synthesis, and the possibility for specificity and optimization due to the combinatorial reactions over natural paclitaxel.

Inventors:
ARAD DORIT (US)
BOLLON ARTHUR P (US)
POLAND BRADLEY W (US)
YOUNG DAVID C (US)
Application Number:
PCT/US2000/019524
Publication Date:
August 16, 2001
Filing Date:
July 17, 2000
Export Citation:
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Assignee:
CYTOCLONAL PHARMACEUTICS INC (US)
ARAD DORIT (US)
BOLLON ARTHUR P (US)
POLAND BRADLEY W (US)
YOUNG DAVID C (US)
International Classes:
C07C233/58; C07C233/87; C07C235/14; C07C271/22; (IPC1-7): C07C271/22; C07C69/78; C07C235/14; C07D493/04
Foreign References:
US5674905A1997-10-07
US5658940A1997-08-19
US4349552A1982-09-14
US5302589A1994-04-12
Other References:
TING-CHAO CHOU ET. AL.: "Computerised Quantitation of Synergism and Antagonism of Taxol, Topotecan and Cisplatin Against Human Teratocarcinoma Cell Growth.", JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol. 86, no. 20, 19 October 1994 (1994-10-19), pages 1517 - 24, XP000983664
M. WANG ET. AL.: "A Unified and Quantitative Receptor Model for the Microtubule Binding of Paclitaxel and Epothilone.", ORGANIC LETTERS, vol. 1, no. 1, January 1999 (1999-01-01), pages 43 - 6, XP000983329
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