Title:
METHOD FOR DESIGNING A VACCINE
Document Type and Number:
WIPO Patent Application WO/2015/082745
Kind Code:
A8
Abstract:
The invention relates to a method for computer-assisted design of a vaccine against a disease which, on the basis of a plurality of amino acid chains S1...Sk obtained from patients infected with said disease and a set Τ of target epitopes, each epitope being an amino acid chain, includes the steps of: i) obtaining, by means of a combinatorial optimisation method, a plurality of amino acid chains having the shortest possible length relative to the combinatorial optimisation method used, which have as subchains at least one integer λ of epitopes from the set Τ in each of the sequences Si, wherein the value of λ is such that the length of the resulting chain is long enough to develop an immune response but not long enough to develop an autoimmune response; ii) selecting, among the plurality of chains obtained in the preceding step, at least one final candidate for immunogen via at least one standard experimental method; and iii) developing the vaccine from said immunogen.
Inventors:
LEGARRETA SOLAGUREN LEIRE (ES)
MARTÍNEZ FERNÁNDEZ LUIS (ES)
MARTÍNEZ DE LA FUENTE MARTÍNEZ ILDEFONSO (ES)
MILANIC MARTIN (SI)
MARTÍNEZ FERNÁNDEZ LUIS (ES)
MARTÍNEZ DE LA FUENTE MARTÍNEZ ILDEFONSO (ES)
MILANIC MARTIN (SI)
Application Number:
PCT/ES2014/070888
Publication Date:
August 06, 2015
Filing Date:
December 02, 2014
Export Citation:
Assignee:
UNIV PAIS VASCO (ES)
UNIVERZA NA PRIMORSKEM UNI DEL LITORALE (SI)
UNIVERZA NA PRIMORSKEM UNI DEL LITORALE (SI)
International Classes:
A61K39/00; G06F19/00; G16B20/00
Attorney, Agent or Firm:
VALLEJO LÓPEZ, Juan Pedro (Madrid, ES)
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