Title:
METHOD FOR DETECTING MUTATION AND METHYLATION OF TUMOR SPECIFIC GENE IN CTDNA
Document Type and Number:
WIPO Patent Application WO/2021/073490
Kind Code:
A1
Abstract:
Disclosed in the present invention is a method for detecting mutation and methylation of a tumor specific gene in ctDNA. The method is a method for simultaneously detecting mutation (including various mutation forms such as point mutation, insertion and deletion mutations, and HBV integration) and/or methylation of a tumor specific gene in ctDNA in one sample. The demand for the sample size is low; and a MC library prepared with the method can support 10-20 subsequent detections, the result of each detection can represent a mutation status of all original ctNDA samples and a methylation modification status of an enzyme cutting site coverage area, and no reduction in sensitivity and specificity is caused. The present invention has important clinical significance for early tumor screening, illness tracking, curative effect evaluation, prognosis prediction, etc., and has a great application value.
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Inventors:
JIAO YUCHEN (CN)
QU CHUNFENG (CN)
WANG YUTING (CN)
WANG PEI (CN)
CHEN KUN (CN)
SONG QIANQIAN (CN)
LIU HUI (CN)
WANG JINGJING (CN)
WANG SIZHEN (CN)
QU CHUNFENG (CN)
WANG YUTING (CN)
WANG PEI (CN)
CHEN KUN (CN)
SONG QIANQIAN (CN)
LIU HUI (CN)
WANG JINGJING (CN)
WANG SIZHEN (CN)
Application Number:
PCT/CN2020/120560
Publication Date:
April 22, 2021
Filing Date:
October 13, 2020
Export Citation:
Assignee:
CANCER HOSPITAL CHINESE ACEDEMY OF MEDICAL SCIENCES (CN)
GENETRON HEALTH BEIJING CO LTD (CN)
GENETRON HEALTH BEIJING CO LTD (CN)
International Classes:
C40B50/06
Foreign References:
| CN108103060A | 2018-06-01 | |||
| CN107223159A | 2017-09-29 |
Other References:
XU R HWEI WKRAWCZYK M ET AL.: "Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma[J", NATURE MATERIALS, vol. 16, no. 11, 2017, pages 1155, XP055784350, DOI: 10.1038/nmat4997
Attorney, Agent or Firm:
JEEKAI&PARTNERS (CN)
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