Title:
A METHOD FOR DETECTING TRANSPOSABLE GENETIC MATERIAL IN A BIOLOGICAL SAMPLE BASED ON CODON OPTIMALITY
Document Type and Number:
WIPO Patent Application WO/2021/206192
Kind Code:
A1
Abstract:
The present invention relates to a novel method for detecting transposable or non-self genetic material in a biological sample. The method of the present invention may be effectively used for detecting transposons with highly enhanced accuracy, based on the reduced codon optimality of transposons. The method of the present invention may be applied as reliable research tool for investigating genetic transpositional issue in an organism, or a methodology for diagnosing a disease accompanying with genetic transposition or infectious issues with foreign genome invasion.
Inventors:
KIM EUN YU (KR)
CHO JUNGNAM (KR)
CHO JUNGNAM (KR)
Application Number:
PCT/KR2020/004782
Publication Date:
October 14, 2021
Filing Date:
April 08, 2020
Export Citation:
Assignee:
CAS CENTER FOR EXCELLENCE IN MOLECULAR PLANT SCIENCES (CN)
International Classes:
C12Q1/6827; C12Q1/6806; G16B25/10; G16B30/10; G16B40/20
Domestic Patent References:
| WO2003093451A2 | 2003-11-13 |
Other References:
JIA J; XUE Q: "Codon usage biases of transposable elements and host nuclear genes in Arabidopsis thaliana and Oryza sativa", GENOMICS, PROTEOMICS & BIOINFORMATICS, vol. 7, no. 4, 1 December 2009 (2009-12-01), pages 175 - 184, XP026913948, ISSN: 1672-0229, DOI: 10.1016/S1672-0229(08)60047-9
ADAM D. EWING: "Transposable element detection from whole genome sequence data", MOBILE DNA, vol. 6, no. 1, 24, 1 December 2015 (2015-12-01), pages 1 - 9, XP055753423, DOI: 10.1186/s13100-015-0055-3
YURIKO HARIGAYA; ROY PARKER: "Analysis of the association between codon optimality and mRNA stability in Schizosaccharomyces pombe", BMC GENOMICS, vol. 17, no. 1, 8 November 2016 (2016-11-08), pages 1 - 16, XP021238096, DOI: 10.1186/s12864-016-3237-6
BERGMAN C M; QUESNEVILLE H: "Discovering and detecting transposable elements in genome sequences", BRIEFINGS IN BIOINFORMATICS, vol. 8, no. 6, 10 October 2007 (2007-10-10), pages 382 - 392, XP055753421, ISSN: 1467-5463, DOI: 10.1093/bib/bbm048
ADAM D. EWING: "Transposable element detection from whole genome sequence data", MOBILE DNA, vol. 6, no. 1, 24, 1 December 2015 (2015-12-01), pages 1 - 9, XP055753423, DOI: 10.1186/s13100-015-0055-3
YURIKO HARIGAYA; ROY PARKER: "Analysis of the association between codon optimality and mRNA stability in Schizosaccharomyces pombe", BMC GENOMICS, vol. 17, no. 1, 8 November 2016 (2016-11-08), pages 1 - 16, XP021238096, DOI: 10.1186/s12864-016-3237-6
BERGMAN C M; QUESNEVILLE H: "Discovering and detecting transposable elements in genome sequences", BRIEFINGS IN BIOINFORMATICS, vol. 8, no. 6, 10 October 2007 (2007-10-10), pages 382 - 392, XP055753421, ISSN: 1467-5463, DOI: 10.1093/bib/bbm048
Attorney, Agent or Firm:
CHUNG HYUN PATENT & LAW FIRM (KR)
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