Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
METHOD FOR EFFECTIVELY INTERVENING DIABETES BY USING L-TYPE AMINO ACID TRANSPORTER INHIBITOR OR ANTAGONIST
Document Type and Number:
WIPO Patent Application WO/2022/061962
Kind Code:
A1
Abstract:
A method for effectively intervening diabetes by using an L-type amino acid transporter inhibitor or antagonist, and specifically, a use of an L-type amino acid transporter inhibitor or antagonist is provided, which is used for preparing a composition or a preparation, and the composition or preparation is used to prevent and/or treat diabetes, and can improve the number of pancreatic β cells. It has been discovered for the first time that the L-type amino acid transporter inhibitor or antagonist can effectively reduce fasting blood glucose in mammals and can effectively treat diabetes.

Inventors:
CHEN YAN (CN)
WEI SIYING (CN)
WANG TAO (CN)
Application Number:
PCT/CN2020/119572
Publication Date:
March 31, 2022
Filing Date:
September 30, 2020
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
SHANGHAI INST OF NUTRITION AND HEALTH CHINESE ACADEMY OF SCIENCES (CN)
International Classes:
A61K45/00; A61P3/10; C12Q1/02; G01N33/68
Foreign References:
US20190059433A12019-02-28
US20170348398A12017-12-07
CN110215448A2019-09-10
Other References:
CASTAÑO-MARTINEZ TERESA, SCHUMACHER FABIAN, SCHUMACHER SILKE, KOCHLIK BASTIAN, WEBER DANIELA, GRUNE TILMAN, BIEMANN RONALD, MCCANN: "Methionine restriction prevents onset of type 2 diabetes in NZO mice", THE FASEB JOURNAL, vol. 33, no. 6, 1 June 2019 (2019-06-01), US, pages 7092 - 7102, XP055915488, ISSN: 0892-6638, DOI: 10.1096/fj.201900150R
WU, XIN ET AL.: "Progress on L-Type Amino Acid Transporter-1", LIFE SCIENCES, vol. 20, no. 2, 30 April 2008 (2008-04-30), pages 253 - 257, XP055915498
YAMAMOTO YU, SAWA RAN, WAKE IKUMI, MORIMOTO AYAKA, OKIMURA YASUHIKO: "Glucose-mediated inactivation of AMP-activated protein kinase reduces the levels of L-type amino acid transporter 1 mRNA in C2C12 cells", NUTRITION RESEARCH, vol. 47, 1 November 2017 (2017-11-01), AMSTERDAM, NL, pages 13 - 20, XP055915501, ISSN: 0271-5317, DOI: 10.1016/j.nutres.2017.08.003
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
Download PDF: