Title:
METHOD FOR THE ENANTIOMER SEPARATION OF CIS-8-BENZYL-7,9-DIOXO-2,8-DIAZABICYCLO[4.3.0]NONANE
Document Type and Number:
WIPO Patent Application WO2000076996
Kind Code:
A3
Abstract:
The invention relates to a method for the enantiomer separation of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane (also described below as cis-6-benzyl-5,7-dioxooctahydropyrrolo[3,4-b]pyridine or dioxopyrrolopiperidine). The invention also relates to a method for producing (1S, 6R)- and (1R, 6S)-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane using the above method. The invention further relates to the (-)-2,3:4,6-di-O-isopropylidene-2-keto-L- gulonic acid salts of (1S, 6R)- and (1R, 6S)-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane and to a method for producing the same. Finally, the invention relates to a method for the enantiomer enrichment of (1S, 6R)-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]-nonane.
Inventors:
FEY PETER (DE)
Application Number:
PCT/EP2000/005116
Publication Date:
April 12, 2001
Filing Date:
June 05, 2000
Export Citation:
Assignee:
BAYER AG (DE)
FEY PETER (DE)
FEY PETER (DE)
International Classes:
C07D471/04; C07H9/04; (IPC1-7): C07D471/04
Domestic Patent References:
| WO1993013087A1 | 1993-07-08 |
Foreign References:
| EP0550903A1 | 1993-07-14 | |||
| US3682925A | 1972-08-08 |
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