Title:
METHOD FOR ENHANCING ACTIVITY IN GRAFT
Document Type and Number:
WIPO Patent Application WO/2021/065976
Kind Code:
A1
Abstract:
The purpose of the present disclosure is to provide a method for enhancing the activity in a graft, particularly in a sheet-like cell culture containing a somatic cell, the enhanced activity being selected from a group consisting of cytokine productivity, proliferation potency, engraftment properties, angiogenic capabilities and tissue regeneration capabilities. The foregoing has been achieved by a method involving a step for incubating a graft at 25°C or higher.
Inventors:
OYAMA KENJI (JP)
MATSUDA ISAMU (JP)
MATSUDA ISAMU (JP)
Application Number:
PCT/JP2020/037063
Publication Date:
April 08, 2021
Filing Date:
September 30, 2020
Export Citation:
Assignee:
TERUMO CORP (JP)
International Classes:
A61P9/00; A61K35/12; A61K47/42; A61L27/22; A61L27/24; A61L27/38; A61L27/52; A61L27/54; A61L27/58; C12N5/071
Foreign References:
| JP2016052271A | 2016-04-14 | |||
| JP2011172925A | 2011-09-08 |
Other References:
GARRITY, J.T. ET AL.: "Improved Osteochondral Allograft Preservation Using Serum-Free Media at Body Temperature", AM J SPORTS MED, vol. 40, no. 11, 2012, pages 2542 - 2548, XP055815424, ISSN: 0363-5465
JACKSON, C. ET AL.: "Effect of Storage Temperature on Cultured Epidermal Cell Sheets Stored in Xenobiotic-Free Medium", PLOS ONE, vol. 9, no. 8, 2014, pages 1 - 9, XP055815427, ISSN: 1932-6203
GO, MASAHIRO: "Research and development of cultivated autologous oral mucosal epithelial sheet using amniotic membranes as a substrate", THE 2016 PROJECT REPORT OF PROJECT FOCUSED ON DEVELOPING KEY EVALUATION TECHNOLOGY: EVALUATION FOR INDUSTRIALIZATION IN THE FIELD OF REGENERATIVE MEDICINE (DEVELOPMENT OF KEY EVALUATION TECHNOLOGY FOR INDUSTRIALIZATION IN THE FIELD OF REGENERATIVE ME, 2017, pages 1 - 14
JACKSON, C. ET AL.: "Effect of Storage Temperature on Cultured Epidermal Cell Sheets Stored in Xenobiotic-Free Medium", PLOS ONE, vol. 9, no. 8, 2014, pages 1 - 9, XP055815427, ISSN: 1932-6203
GO, MASAHIRO: "Research and development of cultivated autologous oral mucosal epithelial sheet using amniotic membranes as a substrate", THE 2016 PROJECT REPORT OF PROJECT FOCUSED ON DEVELOPING KEY EVALUATION TECHNOLOGY: EVALUATION FOR INDUSTRIALIZATION IN THE FIELD OF REGENERATIVE MEDICINE (DEVELOPMENT OF KEY EVALUATION TECHNOLOGY FOR INDUSTRIALIZATION IN THE FIELD OF REGENERATIVE ME, 2017, pages 1 - 14
Attorney, Agent or Firm:
KUZUWA, Kiyoshi (JP)
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