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Title:
METHOD FOR EVALUATING ACTIVITY OF FLUORINATING AGENT AND METHOD FOR MANUFACTURING ESTER COMPOUND
Document Type and Number:
WIPO Patent Application WO/2021/200640
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an economical, convenient and reproducible method for evaluating an activity as a fluorinating agent. Provided is a method for evaluating an activity of a fluorinating agent, the method including: a fluorinating step for subjecting a fluorinating agent to a reaction with a carboxylic acid represented by formula (1) below to convert the fluorinating agent into a carboxylic acid fluoride; an esterifying step for subjecting the mixture after the above step to a reaction with an alcohol represented by R1OH (wherein R1 is a C1-4 alkyl group) to convert the above carboxylic acid fluoride into an ester compound; and a step for quantitatively analyzing the concentration of the ester compound contained in the mixture after the above esterifying step to evaluate an activity as a fluorinating agent through comparison of same with a theoretical concentration of the ester compound obtained from the above fluorinating agent and carboxylic acid. (Here Ra, Rb, Rc, Rd and Re each represent a given group.)

Inventors:
MORI SATORU (JP)
Application Number:
PCT/JP2021/012828
Publication Date:
October 07, 2021
Filing Date:
March 26, 2021
Export Citation:
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Assignee:
UBE INDUSTRIES (JP)
International Classes:
C07C67/14; C07C69/78; C07C381/00
Domestic Patent References:
WO2018186331A12018-10-11
Foreign References:
JP2009544735A2009-12-17
JP2011157292A2011-08-18
JP2000103748A2000-04-11
JP2003064034A2003-03-05
Other References:
TERUO UMEMOTO, SINGH RAJENDRA P., XU YONG, SAITO NORIMICHI: "Discovery of 4- tert -Butyl-2,6-dimethylphenylsulfur Trifluoride as a Deoxofluorinating Agent with High Thermal Stability as Well as Unusual Resistance to Aqueous Hydrolysis, and Its Diverse Fluorination Capabilities Including Deoxofluoro-Arylsulfinylation with High Stereoselectivity", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ¬AMERICAN CHEMICAL SOCIETY|, vol. 132, no. 51, 29 December 2010 (2010-12-29), pages 18199 - 18205, XP055083243, ISSN: 00027863, DOI: 10.1021/ja106343h
MIEKO ARISAWA; YUI IGARASHI; HARUKI KOBAYASHI; TORU YAMADA; KENTARO BANDO; TAKUYA ICHIKAWA; MASAHIKO YAMAGUCHI;: "Equilibrium shift in the rhodium-catalyzed acyl transfer reactions", TETRAHEDRON, ELSEVIER SIENCE PUBLISHERS, AMSTERDAM, NL, vol. 67, no. 40, 12 July 2011 (2011-07-12), AMSTERDAM, NL , pages 7846 - 7859, XP028282082, ISSN: 0040-4020, DOI: 10.1016/j.tet.2011.07.031
Attorney, Agent or Firm:
TSUKUNI & ASSOCIATES et al. (JP)
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