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Patent Searching and Data


Title:
METHOD OF EXAMINING INFLAMMATORY DISEASE AND METHOD OF SCREENING REMEDY FOR INFLAMMATORY DISEASE
Document Type and Number:
WIPO Patent Application WO/2006/075626
Kind Code:
A1
Abstract:
A gene polymorphism on a Toll-like receptor gene is analyzed and an inflammatory disease is examined based on the results of the analysis. A remedy for an inflammatory disease is screened by selecting a substance capable of altering the interaction between Toll-like receptor and galectin-2.

Inventors:
TANAKA TOSHIHIRO (JP)
OZAKI KOICHI (JP)
IIDA ARITOSHI (JP)
HORI MASATSUGU (JP)
NAKAMURA YUSUKE (JP)
Application Number:
PCT/JP2006/300224
Publication Date:
July 20, 2006
Filing Date:
January 11, 2006
Export Citation:
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Assignee:
RIKEN (JP)
TANAKA TOSHIHIRO (JP)
OZAKI KOICHI (JP)
IIDA ARITOSHI (JP)
HORI MASATSUGU (JP)
NAKAMURA YUSUKE (JP)
International Classes:
C12N15/09; C12Q1/68; G01N33/15; G01N33/50; C12Q1/02
Foreign References:
Other References:
EDFELDT K. ET AL.: "Expression of Toll-like receptors in human atherosclerotic lesions and the relevance to myocardial infarction", EUROPEAN HEART JOURNAL, vol. 24, no. ABSTR. SUPPL., 2003, pages 156, ABSTR. NO. P941, XP004529390
HAMANN L. ET AL.: "Rapid and inexpensive real-time PCR for genotyping functional polymorphisms within the Toll-like receptor -2, -4, and -9 genes", J. IMMUNOL. METHODS, vol. 285, no. 2, 2004, pages 281 - 291, XP004491171
BARBER R.C. ET AL.: "TLR4 and TNF-alpha polymorphisms are associated with an increased risk for severe sepsis following burn injury", J. MED. GENET., vol. 41, no. 11, 2004, pages 808 - 813, XP003004579
HALLMAN M. ET AL.: "Toll-like receptors as sensors of pathogens", PEDIATR. RES., vol. 50, no. 3, 2001, pages 315 - 321, XP002228543
ANDERS H.J. ET AL.: "Signaling danger: toll-like receptors and their potential roles in kidney disease", J. AM. SOC. NEPHROL., vol. 15, no. 4, 2004, pages 854 - 867, XP003004580
OZAKI K. ET AL.: "Taikeiteki SNP Kaiseki ni yoru Shinkinkosoku Kanjusei Idenshigun no Dotei to sono Kinokaiseki, Lymphotoxin-alpha oyobi sono Ketsugobunshi Galectin-2 to Shinkinkosoku", PROTEIN, NUCLEIC AND ENZYME, vol. 49, no. 14, 2004, pages 2215 - 2221, XP003004581
OZAKI K. ET AL.: "Tainshi Idenbyo to shite no Junkanki Shikkan Shinkinkosoku", SAISHIN IGAKU, vol. 60, no. THE SEPTEMBER, 2005, pages 2026 - 2034, XP003004582
Attorney, Agent or Firm:
Kawaguchi, Yoshiyuki (4-10 Higashi Nihonbashi 3-chom, Chuo-ku Tokyo 04, JP)
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