Title:
METHOD FOR EXTENDING TELOMERE OF CELL
Document Type and Number:
WIPO Patent Application WO/2020/071652
Kind Code:
A1
Abstract:
Disclosed are a method for extending the telomeres of cells and cells having telomeres extended by physical stimuli, the method comprising the steps of: providing direct or indirect physical stimuli for cells; and incubating a mixture of the cells and a medium for a predetermined period of time, wherein the providing of direct physical stimuli refers to applying physical stimuli to a medium containing cells and the providing of indirect physical stimuli refers to applying physical stimuli to a cell-free medium which is then mixed with the cells. The method for extending telomeres of cells according to the present invention is simple and superior in terms of time, cost, effect efficiency, and safety, compared to conventional methods. Moreover, the method of the present invention induces cell division and has an anti-senescence effect in addition to extending telomeres and as such, can be expected to alleviate and prevent various senescence-associated diseases and symptoms as well as solving problems with shortened telomeres.
Inventors:
LEE YONG SEUNG (KR)
Application Number:
PCT/KR2019/011681
Publication Date:
April 09, 2020
Filing Date:
September 10, 2019
Export Citation:
Assignee:
STEMON INC (KR)
International Classes:
C12N13/00; C12N5/077
Domestic Patent References:
| WO1995013383A1 | 1995-05-18 |
Foreign References:
| US20140242155A1 | 2014-08-28 | |||
| KR101855967B1 | 2018-05-10 | |||
| US20180280413A1 | 2018-10-04 | |||
| EP2959005A1 | 2015-12-30 | |||
| KR20180123512A | 2018-11-16 | |||
| KR101855967B1 | 2018-05-10 |
Other References:
MURILLO-ORTIZ, B. ET AL.: "Increased telomere length and proliferative potential in peripheral blood mononuclear cells of adults of different ages stimulated with concanavalin A", BMC GERIATRICS, vol. 13, 2013, pages 1 - 5, XP021163371
KHAVINSON, V. K. ET AL.: "Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells", BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, vol. 135, no. 6, June 2003 (2003-06-01), pages 590 - 592, XP055579199, DOI: 10.1023/A:1025493705728
LEE ET AL.: "An ultra-effective method of generating extramultipotent cells from human fibroblasts by ultrasound", BIOMATERIALS, 2017
KHAVINSON, V. K. ET AL.: "Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells", BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, vol. 135, no. 6, June 2003 (2003-06-01), pages 590 - 592, XP055579199, DOI: 10.1023/A:1025493705728
LEE ET AL.: "An ultra-effective method of generating extramultipotent cells from human fibroblasts by ultrasound", BIOMATERIALS, 2017
Attorney, Agent or Firm:
JIDAM IP LAW FIRM (KR)
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