Title:
METHOD FOR EXTRACTING CRUDE PRODUCT OF GLYCYRRHIZIC ACID AND GLYCYRRHIZIC FLAVONE FROM LICORICE AND PURIFYING TO OBTAIN GLYCYRRHIZINATE
Document Type and Number:
WIPO Patent Application WO/2021/134407
Kind Code:
A1
Abstract:
A method for extracting a crude product of glycyrrhizic acid and glycyrrhizic flavone from licorice and purifying to obtain glycyrrhizinate. In the method, a medicinal material of licorice and an organic solvent are mixed at a certain ratio, a pH regulator is added to the mixing system to control the pH value of the system at ≤4, and glycyrrhizic acid in the medicinal material is extracted in multiple stages; a first stage extraction liquid is used for the further purification of glycyrrhizic acid and for the concentration and enrichment of a glycyrrhizic flavone component, and a subsequent second stage glycyrrhizic acid extraction liquid can be used continuously in the next round/batch of extracting the medicinal material of licorice. The method for extracting a crude product of glycyrrhizic acid achieves the high-efficiency extraction of glycyrrhizic acid and glycyrrhizic flavone components.
Inventors:
LIU WEI (CN)
XU JING (CN)
TAN DONGMING (CN)
TAN HAILIANG (CN)
LOU MINAN (CN)
LI SONGWU (CN)
XU JING (CN)
TAN DONGMING (CN)
TAN HAILIANG (CN)
LOU MINAN (CN)
LI SONGWU (CN)
Application Number:
PCT/CN2019/130346
Publication Date:
July 08, 2021
Filing Date:
December 31, 2019
Export Citation:
Assignee:
CHINA MEHECO CO LTD (CN)
BEIJING DIACRID MEDICAL TECH CO LTD (CN)
BEIJING DIACRID MEDICAL TECH CO LTD (CN)
International Classes:
C07J63/00; A61K36/484; A61P1/04; A61P29/00; A61P31/04; A61P35/00; A61P39/06; C07H1/08; C07H15/256; G01N30/02
Foreign References:
| CN111100181A | 2020-05-05 | |||
| CN110934903A | 2020-03-31 | |||
| CN111072731A | 2020-04-28 | |||
| CN104479033A | 2015-04-01 | |||
| CN110452282A | 2019-11-15 | |||
| CN1524870A | 2004-09-01 | |||
| JPS57144297A | 1982-09-06 |
Other References:
LI, XUEYU: "Taxonomy and Experimental Biology of the Genus Glycyrrhiza L.", 31 January 2015, FUDAN PRESS, CN, ISBN: 978-7-309-10982-5, article LI, XUEYU: "Study on Extraction and Determination of Chemical Constituents in Glycyrrhiza Uralensis", pages: 310 - 321, XP009529203
Attorney, Agent or Firm:
GENUINEWAYS INC. (CN)
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