Title:
A METHOD OF IDENTIFYING A FLAVIVIRUS INFECTION, AND RELATED PEPTIDES, KITS AND COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO/2020/209801
Kind Code:
A3
Abstract:
There is provided a method of identifying a flavivirus infection selected from Zika virus (ZIKV), Dengue virus (DENV) and combination thereof in a subject, the method comprising determining whether a sample of the subject reacts with a peptide associated with a certain relative binding capacity. Also claimed are kits, isolated peptides, immune system stimulating compositions comprising specific peptides and a method of distinguishing ZIKV infection from DENV infection.
Inventors:
NG FONG POH (SG)
AMRUN SITI NAQIAH (SG)
YEE WEARN XIN (SG)
AMRUN SITI NAQIAH (SG)
YEE WEARN XIN (SG)
Application Number:
PCT/SG2020/050221
Publication Date:
November 12, 2020
Filing Date:
April 10, 2020
Export Citation:
Assignee:
AGENCY SCIENCE TECH & RES (SG)
International Classes:
G01N33/569; A61K38/04; A61K39/12; A61P31/14; C07K4/02
Domestic Patent References:
| WO2018026845A1 | 2018-02-08 |
Other References:
FREDDY A. MEDINA, FRANCES VILA, JORGE L. MUÑOZ-JORDÁN: "Abstract 1624 : Serological discrimination of Dengue and Zika infections", AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, vol. 99, no. 4, 1 October 2018 (2018-10-01), pages 511, XP055859097, DOI: 10.4269/AJTMH.ABSTRACT2018
LEE, A.J. ET AL.: "Identification of diagnostic peptide regions that distinguish Zika virus from related mosquito-borne Flaviviruses", PLOS ONE, vol. 12, no. 5, 31 May 2017 (2017-05-31), pages 1 - 18, XP055577090, DOI: 10.1371/JOURNAL.PONE.0178199
NISCHAY MISHRA CACIULA ADRIAN; PRICE ADAM; THAKKAR RIDDHI; NG JAMES; CHAUHAN LOKENDRA V; JAIN KOMAL; CHE XIAOYU; ESPINOSA DIEGO A;: "Diagnosis of Zika Virus Infection by Peptide Array and Enzyme-Linked Immunosorbent Assay", MBIO, vol. 9, no. 2, 6 March 2018 (2018-03-06), pages 1 - 16, XP055563669, DOI: 10.1128/MBI0.00095-18
AMRUN, S.N. ET AL.: "Novel differential linear B- cell epitopes to identify Zika and dengue virus infections in patient", CLINICAL & TRANSLATIONAL IMMUNOLOGY, vol. 8, no. 7, e1066, 26 July 2019 (2019-07-26), pages 1 - 15, XP055760060, DOI: 10.1002/CTi2.1066
LEE, A.J. ET AL.: "Identification of diagnostic peptide regions that distinguish Zika virus from related mosquito-borne Flaviviruses", PLOS ONE, vol. 12, no. 5, 31 May 2017 (2017-05-31), pages 1 - 18, XP055577090, DOI: 10.1371/JOURNAL.PONE.0178199
NISCHAY MISHRA CACIULA ADRIAN; PRICE ADAM; THAKKAR RIDDHI; NG JAMES; CHAUHAN LOKENDRA V; JAIN KOMAL; CHE XIAOYU; ESPINOSA DIEGO A;: "Diagnosis of Zika Virus Infection by Peptide Array and Enzyme-Linked Immunosorbent Assay", MBIO, vol. 9, no. 2, 6 March 2018 (2018-03-06), pages 1 - 16, XP055563669, DOI: 10.1128/MBI0.00095-18
AMRUN, S.N. ET AL.: "Novel differential linear B- cell epitopes to identify Zika and dengue virus infections in patient", CLINICAL & TRANSLATIONAL IMMUNOLOGY, vol. 8, no. 7, e1066, 26 July 2019 (2019-07-26), pages 1 - 15, XP055760060, DOI: 10.1002/CTi2.1066
Attorney, Agent or Firm:
DONALDSON & BURKINSHAW LLP (SG)
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