Title:
METHOD FOR THE IN VITRO PRODUCTION OF CARTILAGE-LIKE TISSUE
Document Type and Number:
WIPO Patent Application WO/2004/104188
Kind Code:
A1
Abstract:
A method for the in vitro production of cartilage-like tissue is disclosed. Said method comprises the cultivation of chondrogenic cells in presence of chondroitin sulphate, preferably chondroitin-4-sulphate and/or chondroitin-6-sulphate. The resulting cartilage-like tissue can be used for the repair of chondral and/or osteochondral defects in subjects.
Inventors:
HAEUSELMANN HANS JOERG (CH)
STODDART MARTIN (CH)
HEDBOM ERIK (CH)
STODDART MARTIN (CH)
HEDBOM ERIK (CH)
Application Number:
PCT/IB2003/003455
Publication Date:
December 02, 2004
Filing Date:
July 30, 2003
Export Citation:
Assignee:
HAEUSELMANN HANS JOERG (CH)
STODDART MARTIN (CH)
HEDBOM ERIK (CH)
STODDART MARTIN (CH)
HEDBOM ERIK (CH)
International Classes:
A61L27/28; A61L27/38; A61P19/00; C12M3/00; C12M3/08; C12N5/00; C12N5/077; A61K35/12; (IPC1-7): C12N5/08; A61K35/32; A61L27/38; A61P19/00
Domestic Patent References:
| WO2003042376A1 | 2003-05-22 | |||
| WO1995033821A1 | 1995-12-14 |
Other References:
LIU HONGXIANG ET AL: "Re-expression of differentiated proteoglycan phenotype by dedifferentiated human chondrocytes during culture in alginate beads", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1425, no. 3, 27 November 1998 (1998-11-27), &, pages 505 - 515, XP002274139, ISSN: 0006-3002
LEE DAVID A ET AL: "Expansion of chondrocytes for tissue engineering in alginate beads enhances chondrocytic phenotype compared to conventional monolayer techniques.", ACTA ORTHOPAEDICA SCANDINAVICA, vol. 74, no. 1, February 2003 (2003-02-01), &, pages 6 - 15, XP002274140, ISSN: 0001-6470
LEE DAVID A ET AL: "Expansion of chondrocytes for tissue engineering in alginate beads enhances chondrocytic phenotype compared to conventional monolayer techniques.", ACTA ORTHOPAEDICA SCANDINAVICA, vol. 74, no. 1, February 2003 (2003-02-01), &, pages 6 - 15, XP002274140, ISSN: 0001-6470
Attorney, Agent or Firm:
E. BLUM & CO. (Zürich, CH)
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