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Title:
METHOD OF INCREASING BIOAVAILABILITY OF ALENDRONATE OR OTHER BIS-PHOSPHONATE BY PREDOSE ADMINISTRATION OF VITAMIN D DERIVATIVE
Document Type and Number:
WIPO Patent Application WO2004058235
Kind Code:
A3
Abstract:
The present invention provides a method of increasing the bioavailability of a bis-phosphonate comprising administering an effective predose of a vitamin D derivative, such as alphacalcidol or calcitriol, and after a time interval, administering a therapeutic dose of bis-phosphonate, such as alendronate. The present invention also relates to the use of vitamin D derivatives and bisphosphonates for the manufacture of medicaments for treating osteoporosis, metastatic bone disease, and Paget's disease.

Inventors:
FLASHNER-BARAK MOSHE (IL)
LERNER ITZHAK E (IL)
ROSENBERGER VERED (IL)
Application Number:
PCT/US2003/040174
Publication Date:
February 24, 2005
Filing Date:
December 16, 2003
Export Citation:
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Assignee:
TEVA PHARMA (US)
TEVA PHARMA (US)
FLASHNER-BARAK MOSHE (IL)
LERNER ITZHAK E (IL)
ROSENBERGER VERED (IL)
International Classes:
A61K31/59; A61K31/593; A61K31/663; (IPC1-7): A61K31/593; A61K31/59; A61K31/663
Domestic Patent References:
WO2001028564A12001-04-26
WO2003007916A12003-01-30
Foreign References:
Other References:
ERBEN R G ET AL: "Prevention of bone loss in ovariectomized rats by combined treatment with risedronate and 1[alpha],25-dihydroxyvitamin D3", JOURNAL OF BONE AND MINERAL RESEARCH 2002 UNITED STATES, vol. 17, no. 8, 2002, pages 1498 - 1511, XP008033377, ISSN: 0884-0431
MALAVOLTA N ET AL: "Calcitriol and alendronate combination treatment in menopausal women with low bone mass", INTERNATIONAL JOURNAL OF TISSUE REACTIONS, vol. 21, no. 2, 1999, pages 51 - 59, XP008033382, ISSN: 0250-0868
NUTI RANUCCIO ET AL: "Effect of treatment with calcitriol combined with low-dosage alendronate in involutional osteoporosis", CLINICAL DRUG INVESTIGATION, vol. 19, no. 1, January 2000 (2000-01-01), pages 55 - 61, XP008033379, ISSN: 1173-2563
FREDIANI BRUNO ET AL: "Effects of combined treatment with calcitriol plus alendronate on bone mass and bone turnover in postmenopausal osteoporosis. Two years of continuous treatment", CLINICAL DRUG INVESTIGATION, vol. 15, no. 3, March 1998 (1998-03-01), pages 235 - 244, XP002955329, ISSN: 1173-2563
MASUD T ET AL: "Effects of cyclical etidronate combined with calcitriol versus cyclical etidronate alone on spine and femoral neck bone mineral density in postmenopausal osteoporotic women", ANNALS OF THE RHEUMATIC DISEASES, vol. 57, no. 6, June 1998 (1998-06-01), pages 346 - 349, XP008033380, ISSN: 0003-4967
GERTZ B J ET AL: "STUDIES OF THE ORAL BIOAVAILABILITY OF ALENDRONATE", CLINICAL PHARMACOLOGY & THERAPEUTICS, MOSBY-YEAR BOOK, ST LOUIS, MO, US, vol. 58, no. 3, September 1995 (1995-09-01), pages 288 - 298, XP001006243, ISSN: 0009-9236
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