METHOD FOR INDUCING PLURIPOTENT STEM CELLS AND PLURIPOTENT STEM CELLS PREPARED BY SAID METHOD

WIPO Patent Application WO/2015/056982

A1

The present invention relates to a method for inducing customized pluripotent stem cells, pluripotent stem cells prepared by the method, and a composition comprising the pluripotent stem cells, wherein the customized pluripotent stem cells are induced by reprogramming differentiated adult cells by using shikimic acid, a plant extract containing shikimic acid, or an extract of plant stem cells and redifferentiated plant stem cells (callus). According to the present invention, since an ovum is not used to prepare pluripotent stem cells having the same abilities as embryonic stem cells, ethical problems can be solved. Most of all, by using a plant stem cell extract which is proven to be harmless to humans, pluripotent stem cells having ensured safety can be prepared. Also, the present invention can be used to develop an immunocompatible cell therapeutic agent customized for each subject. In addition, it is expected that the present invention can be very useful in studying a therapeutic method and identifying the cause of a disease by inducing pluripotent stem cells from a subject having the disease. Also, the present invention relates to a composition containing shikimic acid or a plant extract containing shikimic acid.

KIM AH REUM (KR)
KIM SU NA (KR)
PARK WON SEOK (KR)
KWON YOO WOOK (KR)
PARK YOUNG BAE (KR)
KIM HYO SOO (KR)
PAEK JAE SEUNG (KR)

PCT/KR2014/009702

April 23, 2015

October 16, 2014

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AMOREPACIFIC CORP (KR)
SNU R&DB FOUNDATION (KR)

C12N5/074; A61K35/12; C07C62/32; C12N5/02

US20080095866A1	2008-04-24
KR20110032989A	2011-03-30
KR19980034293U	1998-09-15
KR101121883B1	2012-03-20
KR20070113193A	2007-11-28

XU, Y. N. ET AL.: "ES cell extract-induced expression of pluripotent factors in somatic cells", THE ANATOMICAL RECORD, vol. 292, no. 8, August 2009 (2009-08-01), pages 1229 - 1234, XP055110618
See also references of EP 2977446A4
TAKAHASHI K; YAMANAKA S: "Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors", CELL, vol. 126, 2006, pages 663 - 676
DENIS V. BOCHKOV: "Shikimic acid: review of its analytical, isolation, and purification techniques from plant and microbial sources", J CHEM. BIOL., vol. 5, 2012, pages 5 - 17, XP002759175, DOI: doi:10.1007/s12154-011-0064-8

KIM, SUN-YOUNG (KR)
김순영 (KR)

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