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Title:
METHOD FOR MAINTAINING UNDIFFERENTIATION POTENCY OF MESENCHYMAL STEM CELL EMPLOYING SHAKING SUSPENSION CULTURE
Document Type and Number:
WIPO Patent Application WO/2018/194161
Kind Code:
A1
Abstract:
A method for culturing a mesenchymal stem cell in the form of cell masses while maintaining the undifferentiation potency of the mesenchymal stem cell, said method being characterized in that the mesenchymal stem cell is shaking-suspension-cultured.

Inventors:
NIIBE KUNIMICHI (JP)
EGUSA HIROSHI (JP)
Application Number:
PCT/JP2018/016321
Publication Date:
October 25, 2018
Filing Date:
April 20, 2018
Export Citation:
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Assignee:
UNIV TOHOKU (JP)
International Classes:
C12N5/0775; C12M3/00
Domestic Patent References:
WO2004065586A12004-08-05
Foreign References:
JP2013536696A2013-09-26
JP2005278910A2005-10-13
Other References:
ALIMPERTI, S. ET AL.: "Serum free spheroid suspension culture maintains mesenchymal stem cell proliferation and differentiation potential", BIOTECHNOLOGY PROGRESS, vol. 30, no. 4, 2014, pages 974 - 983, XP009193361
LINY, M. ET AL.: "Expansion in microcarrier-spinner cultures improves the chondrogenic potential of human early mesenchymal stromal cells", CYTOTHERAPY, vol. 18, no. 6, 2016, pages 740 - 753, XP055541714
SHEKARAN, A. ET AL.: "Enhanced in vitro osteogenic differentiation of human fetal MSCs attached to 3D microcarriers versus harvested from 2D monolayers", BMC BIOTECHNOLOGY, vol. 15, no. 102, 2015, pages 1 - 13, XP055541715
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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