Title:
METHOD FOR MANUFACTURING CYCLOPROPANE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2020/050339
Kind Code:
A1
Abstract:
Provided is an industrially useful method for manufacturing (1R,2S)-2-{[((2,4-dimethylpyrimidine-5-yl)oxy}methyl]-2-(3-fluorophenyl)-N-(5-fluoropyridine-2-yl)cyclopropane-1-carboxamide. In the present invention, (1R,2S)-2-{[((2,4-dimethylpyrimidine-5-yl)oxy}methyl]-2-(3-fluorophenyl)-N-(5-fluoropyridine-2-yl)cyclopropane-1-carboxamide (compound [A]) is manufactured by an industrially useful method by way of a novel compound. (Symbols in the formula are as described in the specification.)
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Inventors:
YAMAUCHI KAZUHIRO (JP)
TOMOKAWA JUNICHI (JP)
TOMOKAWA JUNICHI (JP)
Application Number:
PCT/JP2019/034882
Publication Date:
March 12, 2020
Filing Date:
September 05, 2019
Export Citation:
Assignee:
SUMITOMO CHEMICAL CO (JP)
International Classes:
C07C67/347; B01J31/02; B01J31/14; B01J31/22; C07C59/56; C07C61/40; C07C69/753; C07C69/757; C07C309/73; C07D213/75; C07D307/93; C07D401/12; A61K31/506; C07B53/00; C07B61/00
Foreign References:
| US20120165339A1 | 2012-06-28 | |||
| JP2015509939A | 2015-04-02 | |||
| JPS6147279B2 | 1986-10-18 | |||
| JPH09235242A | 1997-09-09 |
Other References:
YU YOSHIDA ET AL.: "Discovery of (1R, 2S)-2-{[(2,4-Dimethyl pyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropir idin-2-yl)cyclopropanecarboxamide(E2006) : A potent and Efficacious Oral Orexin Receptor Antagonist.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, 2015, pages 4648 - 4664, XP055389586
NORIHITO OI ET AL.: "Synthesis and Evaluation of Novel Radioligands for Positron Emission Tomography Imaging of the Orexin-2 Receptor", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, 2013, pages 6371 - 6385, XP055690750
CHEM. COMMUN., 2006, pages 3591 - 3593
JOURNAL OF ORGANIC CHEMISTRY, vol. 65, 2000, pages 5875 - 5878
See also references of EP 3848348A4
NORIHITO OI ET AL.: "Synthesis and Evaluation of Novel Radioligands for Positron Emission Tomography Imaging of the Orexin-2 Receptor", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, 2013, pages 6371 - 6385, XP055690750
CHEM. COMMUN., 2006, pages 3591 - 3593
JOURNAL OF ORGANIC CHEMISTRY, vol. 65, 2000, pages 5875 - 5878
See also references of EP 3848348A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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