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Patent Searching and Data


Title:
METHOD FOR MANUFACTURING DIARYLMETHANE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2019/230864
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a method for manufacturing, inexpensively, efficiently, and on an industrial scale, a compound useful as an intermediate for synthesizing a pharmaceutical ingredient for an anti-diabetic drug or the like, and in order to achieve this purpose, the present invention comprises reducing a compound (2) represented by formula (2) [in which R1, Ar, n, and X are as described in the specification] using a reducing agent in the presence of a titanium compound, and manufacturing a compound (1) represented by formula (1) [in which R1, Ar, and N are as described in the specification].

Inventors:
SEKI MASAHIKO (JP)
Application Number:
PCT/JP2019/021460
Publication Date:
December 05, 2019
Filing Date:
May 30, 2019
Export Citation:
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Assignee:
TOKUYAMA CORP (JP)
International Classes:
C07D333/12
Domestic Patent References:
WO2016178148A12016-11-10
WO2017130217A12017-08-03
WO2010043682A22010-04-22
Foreign References:
JP2010180143A2010-08-19
CN105272960A2016-01-27
JP2012505858A2012-03-08
Other References:
BOTTINO, F. A. ET AL.: "Reductive coupling of aromatic ketones by low-valent titanium salts", JOURNAL OF THE CHEMICAL SOCIETY, 1982, pages 77 - 81, XP055662372, ISSN: 0300-9580
DEHMLOW, E.V. ET AL.: "Mild and Fast Deoxygenation of Aromatic Carbonyl Compounds by Dimethylamine Borane/Titanium Tetrachloride", SYNTHETIC COMMUNICATIONS, vol. 26, no. 8, 1996, pages 1467 - 1472, XP001040326, ISSN: 0039-7911, DOI: 10.1080/00397919608003512
CEM. REV, vol. 117, 2017, pages 1687 - 1764
Attorney, Agent or Firm:
NAGAI Hiroshi et al. (JP)
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