METHOD FOR MANUFACTURING REPAIRING AGENT FOR BIOLOGICAL TISSUE DAMAGE, AND REPAIRING AGENT FOR BIOLOGICAL TISSUE DAMAGE

Title:

METHOD FOR MANUFACTURING REPAIRING AGENT FOR BIOLOGICAL TISSUE DAMAGE, AND REPAIRING AGENT FOR BIOLOGICAL TISSUE DAMAGE

Document Type and Number:

WIPO Patent Application WO/2021/060460

Kind Code:

A1

Abstract:

Provided are a novel repair agent for biological tissue damage, having a markedly higher repairing effect on biological tissue damage than a conventional repairing agent for biological tissue damage, and a method for manufacturing said repairing agent. This method for manufacturing a repairing agent for biological tissue damage has a step for culturing mesenchymal stem cells at an oxygen concentration of less than 5% in a serum-free medium.

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Inventors:

KATO YUKIO (JP)
MAEDA SATOSHI (JP)
TSUJI KOICHIRO (JP)
SHAO JIN CHANG (JP)
NAKASHIMA AYUMU (JP)
MASAKI TAKAO (JP)
DOI SHIGEHIRO (JP)
ISHIUCHI NAOKI (JP)

Application Number:

PCT/JP2020/036252

Publication Date:

April 01, 2021

Filing Date:

September 25, 2020

Export Citation:

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Assignee:

TWO CELLS CO LTD (JP)
UNIV HIROSHIMA (JP)

International Classes:

A61K35/28; A61K48/00; A61P1/02; A61P1/16; A61P3/10; A61P9/10; A61P11/00; A61P11/04; A61P13/12; A61P17/02; A61P19/02; A61P19/08; A61P25/00; A61P25/28; A61P27/02; A61P35/00; A61P37/02; A61P43/00; C12N1/00; C12N5/0775; C12Q1/6837

Domestic Patent References:

WO2014200068A1	2014-12-18
WO2018123968A1	2018-07-05
WO2007080919A1	2007-07-19
WO2011111787A1	2011-09-15
WO2015016357A1	2015-02-05
WO2018123968A1	2018-07-05

Other References:

KOJIMA, YUICHI ET AL.: "Mesenchymal stem cells cultured under hypoxic conditions had a greater therapeutic effect on mice with liver cirrhosis compared to those cultured under normal oxygen conditions", REGENERATIVE THERAPY, vol. 11, 20 September 2019 (2019-09-20), pages 269 - 281, XP055813121

Attorney, Agent or Firm:

HARAKENZO WORLD PATENT & TRADEMARK (JP)

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