Title:
METHOD FOR MEASURING EE VALUE OF CHIRAL MOLECULE
Document Type and Number:
WIPO Patent Application WO/2021/203746
Kind Code:
A1
Abstract:
A method for measuring the ee value of a chiral molecule, the steps comprising: preparing a host solution containing a preset host molecule (S100); adding into the host solution a guest solution having a saturated concentration of a chiral molecule to be measured to produce a solution to be measured having CD signal saturation (S200); measuring a first CD signal strength value of solution to be measured at a preset position on a CD spectrum, and substituting the first CD signal strength value into a preset standard curve equation to calculate the ee value of the chiral molecule to be measured (S300).
Inventors:
JIANG WEI (CN)
WANG LILI (CN)
WANG LILI (CN)
Application Number:
PCT/CN2020/139880
Publication Date:
October 14, 2021
Filing Date:
December 28, 2020
Export Citation:
Assignee:
UNIV SOUTHERN SCI & TECH (CN)
International Classes:
G01N21/19
Domestic Patent References:
| WO2020056012A1 | 2020-03-19 |
Foreign References:
| CN111398181A | 2020-07-10 | |||
| CN109705036A | 2019-05-03 | |||
| CN110297044A | 2019-10-01 |
Other References:
WANG LI-LI, CHEN ZHAO, LIU WEI-ER, KE HUA, WANG SHENG-HUA, JIANG WEI: "Molecular Recognition and Chirality Sensing of Epoxides in Water Using Endo -Functionalized Molecular Tubes", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 139, no. 25, 28 June 2017 (2017-06-28), pages 8436 - 8439, XP055856839, ISSN: 0002-7863, DOI: 10.1021/jacs.7b05021
JO HYUN HWA, LIN CHUNG-YON, ANSLYN ERIC V.: "Rapid Optical Methods for Enantiomeric Excess Analysis: From Enantioselective Indicator Displacement Assays to Exciton-Coupled Circular Dichroism", ACCOUNTS OF CHEMICAL RESEARCH, ACS , WASHINGTON , DC, US, vol. 47, no. 7, 15 July 2014 (2014-07-15), US , pages 2212 - 2221, XP055856840, ISSN: 0001-4842, DOI: 10.1021/ar500147x
LIN CHUNG-YON, GIULIANO MICHAEL W., ELLIS BRYAN D., MILLER SCOTT J., ANSLYN ERIC V.: "From substituent effects to applications: enhancing the optical response of a four-component assembly for reporting ee values", CHEMICAL SCIENCE, ROYAL SOCIETY OF CHEMISTRY, UNITED KINGDOM, vol. 7, no. 7, 1 January 2016 (2016-01-01), United Kingdom , pages 4085 - 4090, XP055856841, ISSN: 2041-6520, DOI: 10.1039/C5SC04629G
CHEN XUAN-XUAN, JIANG YUN-BAO, ANSLYN ERIC V.: "A racemate-rules effect supramolecular polymer for ee determination of malic acid in the high ee region", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 52, no. 85, 1 January 2016 (2016-01-01), UK , pages 12669 - 12671, XP055856842, ISSN: 1359-7345, DOI: 10.1039/C6CC06716F
JO HYUN HWA, LIN CHUNG-YON, ANSLYN ERIC V.: "Rapid Optical Methods for Enantiomeric Excess Analysis: From Enantioselective Indicator Displacement Assays to Exciton-Coupled Circular Dichroism", ACCOUNTS OF CHEMICAL RESEARCH, ACS , WASHINGTON , DC, US, vol. 47, no. 7, 15 July 2014 (2014-07-15), US , pages 2212 - 2221, XP055856840, ISSN: 0001-4842, DOI: 10.1021/ar500147x
LIN CHUNG-YON, GIULIANO MICHAEL W., ELLIS BRYAN D., MILLER SCOTT J., ANSLYN ERIC V.: "From substituent effects to applications: enhancing the optical response of a four-component assembly for reporting ee values", CHEMICAL SCIENCE, ROYAL SOCIETY OF CHEMISTRY, UNITED KINGDOM, vol. 7, no. 7, 1 January 2016 (2016-01-01), United Kingdom , pages 4085 - 4090, XP055856841, ISSN: 2041-6520, DOI: 10.1039/C5SC04629G
CHEN XUAN-XUAN, JIANG YUN-BAO, ANSLYN ERIC V.: "A racemate-rules effect supramolecular polymer for ee determination of malic acid in the high ee region", CHEMICAL COMMUNICATIONS, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 52, no. 85, 1 January 2016 (2016-01-01), UK , pages 12669 - 12671, XP055856842, ISSN: 1359-7345, DOI: 10.1039/C6CC06716F
Attorney, Agent or Firm:
CENFO INTELLECTUAL PROPERTY AGENCY (CN)
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