METHOD FOR MODIFYING SUGAR CHAIN STRUCTURE IN PLANT, AND PLANT PRODUCED BY THE METHOD

Title:

METHOD FOR MODIFYING SUGAR CHAIN STRUCTURE IN PLANT, AND PLANT PRODUCED BY THE METHOD

Document Type and Number:

WIPO Patent Application WO/2010/023910

Kind Code:

A1

Abstract:

Disclosed are a method for reducing or inhibiting the modification of an N-linked sugar chain with fucose in a plant, a transgenic plant in which the fucose modification is reduced or inhibited, and others. The amount of GDP-fucose in a plant cell can be reduced by inhibiting the transcription/translation of a gene encoding an enzyme involved in the synthesis of a sugar nucleotide GDP-fucose through posttranscriptional gene silencing (PTGS), virus-induced gene silencing (VIGS) or transcriptional gene silencing (TGS). In this manner, the modification of a sugar chain such as a glycoprotein sugar chain, a glycolipid sugar chain, an oligosaccharide or a polysaccharide with fucose is reduced or inhibited, thereby producing a glycoprotein or the like in which a fucose-modified part (which can act as an allergen) is removed. It becomes possible to use a medical glycoprotein produced in a plant for clinical purposes.

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Inventors:

MATSUO KOUKI (JP)
MATSUMURA TAKESHI (JP)

Application Number:

PCT/JP2009/004147

Publication Date:

March 04, 2010

Filing Date:

August 26, 2009

Export Citation:

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Assignee:

NAT INST OF ADVANCED IND SCIEN (JP)
MATSUO KOUKI (JP)
MATSUMURA TAKESHI (JP)

International Classes:

C12N15/09; A01H1/00; C07K14/415; C12N5/10; C12P21/00

Domestic Patent References:

WO2007084922A2	2007-07-26
WO2006109695A1	2006-10-19
WO2006109698A1	2006-10-19

Foreign References:

JP2002543760A	2002-12-24
JP2005505234A	2005-02-24

Other References:

ALBERMANN C ET AL.: "Preparative synthesis of GDP-p-L-fucose by recombinant enzymes from enterobacterial sources.", GLYCOBIOLOGY, vol. 10, no. 9, 2000, pages 875 - 881

Attorney, Agent or Firm:

SUDO, MASAHIKO (JP)
Masahiko Sudo (JP)

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