Title:
METHOD FOR MODIFYING T CELL POPULATION
Document Type and Number:
WIPO Patent Application WO/2018/088439
Kind Code:
A1
Abstract:
Provided are: a compound represented by formula (I); a retinoid metabolic pathway inhibitor comprising the same; an agent for increasing the ratio of memory T cells; a prophylactic and/or therapeutic agent for cancer or an infectious disease; a cancer immunotherapeutic adjuvant; an immunopotentiator; and a method for preparing a T cell population wherein the ratio of memory T cells is increased, said method comprising using the compound of formula (I).
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Inventors:
SUGIYAMA HARUO (JP)
FUJIKI FUMIHIRO (JP)
NEYA MASAHIRO (JP)
KOHNO SHINYA (JP)
FUJIKI FUMIHIRO (JP)
NEYA MASAHIRO (JP)
KOHNO SHINYA (JP)
Application Number:
PCT/JP2017/040302
Publication Date:
May 17, 2018
Filing Date:
November 08, 2017
Export Citation:
Assignee:
UNIV OSAKA (JP)
KNC LABORATORIES CO LTD (JP)
KNC LABORATORIES CO LTD (JP)
International Classes:
C07J63/00; A61K31/19; A61K31/44; A61K31/5375; A61P31/00; A61P35/00; A61P37/04; C12N5/0783
Domestic Patent References:
| WO2016104486A1 | 2016-06-30 | |||
| WO2015076325A1 | 2015-05-28 | |||
| WO2010103046A1 | 2010-09-16 | |||
| WO2003106682A1 | 2003-12-24 | |||
| WO2005095598A1 | 2005-10-13 | |||
| WO2007097358A1 | 2007-08-30 | |||
| WO2012046730A1 | 2012-04-12 | |||
| WO2016104486A1 | 2016-06-30 |
Foreign References:
| JP2009529572A | 2009-08-20 | |||
| GB1046413A | 1966-10-26 |
Other References:
HELLER, LUCIE ET AL.: "First Occurrence of a = Furano-glycyrrhetinoate and Its Cytotoxicity", ARCHIV ! DER PHARMAZIE, vol. 348, no. 12, 2015, pages 889 - 896, XP055502614, ISSN: 0365-6233
CSUK, RENE ET AL.: "Synthesis and anti tumor activity = of ring A modified glycyrrhetinic acid derivatives", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, no. 11, 2011, pages 5356 - 5369, XP028324196, ISSN: 0223-5234
CSUK, RENE ET AL.: "Synthesis and Cytotoxic Activity of Methyl Glycyrrhetinate Esterified with Amino Acids", A JOURNAL OF CHEMICAL SCIENCES, vol. 67, no. 7, 2012, pages 731 - 746, XP055502616, ISSN: 0932-0776
ZOU, LI-WEI ET AL.: "Design, synthesis, and = structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterase 2", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 112, 9 February 2016 (2016-02-09), pages 280 - 288, XP029450365, ISSN: 0223-5234
BESEDA, IGOR ET AL.: "Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 18, no. 1, 2010, pages 433 - 454, XP026810735, ISSN: 0968-0896
KIM, HA-OK ET AL.: "Tri terpenoids. XXVIII. Leuckart reaction with glycyrrhetic acid derivatives, Izvestiya Akademii Nauk Kazakhskoi SSR", IZVESTIYA AKADEMII NAUK KAZAKHSKOI SSR. SERIYA KHIMICHESKAYA, vol. 22, no. 5, 1972, pages 86 - 87, XP009515025, ISSN: 0002-3205
TOLSTIKOV, G. A. ET AL.: "Carbon-13 NMR spectra of a series of penta- and hexacyclic triterpenoids glycyrrhetic acid derivatives", KHIMIYA PRIRODNYKH SOEDINENII, vol. 5, 1985, pages 645 - 653, XP009515026, ISSN: 0023-1150
IJICHI, SO ET AL.: "Molecular Design of Sweet Tasting Compounds Based on 3beta-Amino-3beta-deoxy-18beta-glycyrrhetinic Acid: Amido Functionality Eliciting Tremendous Sweetness", CHEMISTRY LETTERS, vol. 34, no. 3, 1 January 2005 (2005-01-01), pages 356 - 357, XP055601243, ISSN: 0366-7022, DOI: 10.1246/cl.2005.356
OKA Y ET AL., IMMUNOGENETICS, vol. 51, no. 2, February 2000 (2000-02-01), pages 99 - 107
See also references of EP 3539974A4
CSUK, RENE ET AL.: "Synthesis and anti tumor activity = of ring A modified glycyrrhetinic acid derivatives", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, no. 11, 2011, pages 5356 - 5369, XP028324196, ISSN: 0223-5234
CSUK, RENE ET AL.: "Synthesis and Cytotoxic Activity of Methyl Glycyrrhetinate Esterified with Amino Acids", A JOURNAL OF CHEMICAL SCIENCES, vol. 67, no. 7, 2012, pages 731 - 746, XP055502616, ISSN: 0932-0776
ZOU, LI-WEI ET AL.: "Design, synthesis, and = structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterase 2", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 112, 9 February 2016 (2016-02-09), pages 280 - 288, XP029450365, ISSN: 0223-5234
BESEDA, IGOR ET AL.: "Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 18, no. 1, 2010, pages 433 - 454, XP026810735, ISSN: 0968-0896
KIM, HA-OK ET AL.: "Tri terpenoids. XXVIII. Leuckart reaction with glycyrrhetic acid derivatives, Izvestiya Akademii Nauk Kazakhskoi SSR", IZVESTIYA AKADEMII NAUK KAZAKHSKOI SSR. SERIYA KHIMICHESKAYA, vol. 22, no. 5, 1972, pages 86 - 87, XP009515025, ISSN: 0002-3205
TOLSTIKOV, G. A. ET AL.: "Carbon-13 NMR spectra of a series of penta- and hexacyclic triterpenoids glycyrrhetic acid derivatives", KHIMIYA PRIRODNYKH SOEDINENII, vol. 5, 1985, pages 645 - 653, XP009515026, ISSN: 0023-1150
IJICHI, SO ET AL.: "Molecular Design of Sweet Tasting Compounds Based on 3beta-Amino-3beta-deoxy-18beta-glycyrrhetinic Acid: Amido Functionality Eliciting Tremendous Sweetness", CHEMISTRY LETTERS, vol. 34, no. 3, 1 January 2005 (2005-01-01), pages 356 - 357, XP055601243, ISSN: 0366-7022, DOI: 10.1246/cl.2005.356
OKA Y ET AL., IMMUNOGENETICS, vol. 51, no. 2, February 2000 (2000-02-01), pages 99 - 107
See also references of EP 3539974A4
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
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