Title:
METHOD FOR PREDICTING EFFICACY OF RHEUMATOID ARTHRITIS THERAPEUTIC DRUG AND BIOMARKER USED THEREIN
Document Type and Number:
WIPO Patent Application WO/2020/116567
Kind Code:
A1
Abstract:
[Problem] To predict the efficacy of a rheumatoid arthritis therapeutic drug, or find a simple and highly reproducible biomarker that can be used to assess the activity of disease conditions and states of rheumatoid arthritis, and provide an effective method. [Solution] A method for predicting the efficacy of a rheumatoid arthritis therapeutic drug on a rheumatoid arthritis patient, the method comprising: a step for measuring the expression level of the MS4A4A gene in peripheral blood derived from the patient before administration of the rheumatoid arthritis therapeutic drug; and a step for measuring the expression level of the MS4A4A gene in peripheral blood derived from the patient after a first period of time has passed since administration of the rheumatoid arthritis therapeutic drug, wherein a reduction in the expression level of the MS4A4A gene after the first period time has passed, indicates a reduction in the value of an index related to rheumatoid arthritis occurring in the patient after a second period of time has passed since administration of the therapeutic drug.
Inventors:
NAKAMURA SEIJI (JP)
UEDA YUMI (JP)
ISHIZAWA YOHEI (JP)
HIRAYAMA MADOKA (JP)
MATOBA RYO (JP)
TAKEUCHI TSUTOMU (JP)
YAMAOKA KUNIHIRO (JP)
AMANO KOICHI (JP)
UEDA YUMI (JP)
ISHIZAWA YOHEI (JP)
HIRAYAMA MADOKA (JP)
MATOBA RYO (JP)
TAKEUCHI TSUTOMU (JP)
YAMAOKA KUNIHIRO (JP)
AMANO KOICHI (JP)
Application Number:
PCT/JP2019/047645
Publication Date:
June 11, 2020
Filing Date:
December 05, 2019
Export Citation:
Assignee:
DNA CHIP RESEARCH INC (JP)
UNIV KEIO (JP)
UNIV SAITAMA MEDICAL (JP)
UNIV KEIO (JP)
UNIV SAITAMA MEDICAL (JP)
International Classes:
C12N15/12; C12Q1/6851; G01N33/53
Domestic Patent References:
| WO2008150491A2 | 2008-12-11 | |||
| WO2017125402A1 | 2017-07-27 |
Foreign References:
| JP2009092508A | 2009-04-30 | |||
| JPS53239B2 | 1978-01-06 |
Other References:
TAKEUCHI, TSUTOMU ET AL.: "Reactivity and DNA chip analysis of biologics for rheumatoid arthritis", JAPANESE JOURNAL OF ALLERGOLOGY, vol. 54, no. 8- 9, 30 September 2005 (2005-09-30), pages 927, XP055713987
BIOSTATISTICS, vol. 8, no. 1, January 2007 (2007-01-01), pages 118 - 27
See also references of EP 3901264A4
BIOSTATISTICS, vol. 8, no. 1, January 2007 (2007-01-01), pages 118 - 27
See also references of EP 3901264A4
Attorney, Agent or Firm:
YAGUCHI Taro (JP)
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