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Title:
METHOD FOR PREDICTING NOVEL CORONAVIRUS NEUTRALIZING ANTIBODY TITERS AND KIT THEREFOR
Document Type and Number:
WIPO Patent Application WO/2022/134241
Kind Code:
A1
Abstract:
Provided are a method for predicting novel coronavirus neutralizing antibody titers and a kit therefor, which belong to the technical field of neutralizing antibody titer prediction. The method for predicting the novel coronavirus neutralizing antibody titers is as follows: first, a biological sample to be tested is provided, and then an expression level of novel coronavirus-specific protein in a serum sample after binding to affinity antibodies is detected; and then the detection result is associated with neutralizing antibody titers so as to predict the neutralizing antibody titers of the novel coronavirus in the biological sample. The method above may well predict the neutralizing antibody result of the novel coronavirus merely by means of serum detection. Compared to existing plaque reduction neutralization tests and pseudovirus based neutralization assay, the present method has the advantages of a simple operation, a fast detection speed, a short detection period, and a safe detection environment, and may be used as an evaluation index for the second recurrence of novel coronavirus vaccination or infection.

Inventors:
YAO HANGPING (CN)
CHEN ZHE (CN)
CHEN HANG (CN)
CAO SHAOWEI (CN)
CHEN QIUQIANG (CN)
SHEN MINGCHENG (CN)
WU YUN (CN)
Application Number:
PCT/CN2021/071877
Publication Date:
June 30, 2022
Filing Date:
January 14, 2021
Export Citation:
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Assignee:
HANGZHOU BAOLIN BIOTECHNOLOGY CO LTD (CN)
International Classes:
G01N33/569; G01N33/543; G01N33/558; G01N33/58
Foreign References:
CN111562368A2020-08-21
CN111521818A2020-08-11
CN111351927A2020-06-30
CN111426844A2020-07-17
CN107533058A2018-01-02
CN111007139A2020-04-14
EP3734286A12020-11-04
EP3715847A12020-09-30
Other References:
MAZZINI LIVIA; MARTINUZZI DONATA; HYSENI INESA; BENINCASA LINDA; MOLESTI ELEONORA; CASA ELISA; LAPINI GIULIA; PIU PIETRO; TROMBETT: "Comparative analyses of SARS-CoV-2 binding (IgG, IgM, IgA) and neutralizing antibodies from human serum samples", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM., NL, vol. 489, 28 November 2020 (2020-11-28), NL , XP086451534, ISSN: 0022-1759, DOI: 10.1016/j.jim.2020.112937
Attorney, Agent or Firm:
CHOFN INTELLECTUAL PROPERTY (CN)
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