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Title:
METHOD FOR PREPARING (1R,3S)-3-AMINOCYCLOPENTANOL HYDROCHLORIDE
Document Type and Number:
WIPO Patent Application WO/2020/132819
Kind Code:
A1
Abstract:
Disclosed is a method for preparing (1R,3S)-3-aminocyclopentanol hydrochloride. The method comprises using amide formed by chiral carboxylic acid and hydroxylamine as a chiral source, quickly obtaining a chiral Diels-Alder reaction product in a copper-catalyzed oxidation reaction system, and then subjecting same to reduction, alkaline deprotection, and acidification reactions to obtain the target product.

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Inventors:
ZHOU ZHANGTAO (CN)
YE WEIPING (CN)
FEI ANJIE (CN)
WANG YANG (CN)
QIAN ZHONGWEN (CN)
ZHOU XINGBAO (CN)
Application Number:
PCT/CN2018/123142
Publication Date:
July 02, 2020
Filing Date:
December 24, 2018
Export Citation:
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Assignee:
GUANGDONG RAFFLES PHARMATECH CO LTD (CN)
International Classes:
C07C215/44; C07C213/02; C07C231/08; C07C235/36; C07C249/08; C07C251/40; C07D207/16; C07D498/08
Foreign References:
CN109020911A2018-12-18
CN102633657A2012-08-15
CN103923055A2014-07-16
Other References:
CHARLES P. FRAZIER ET AL: "Copper-Catalyzed Aerobic Oxidation of N-Substituted Hydroxylamines: Efficient and Practical Access to Nitroso Compounds", ORGANIC LETTERS, vol. 14, no. 14, 11 July 2012 (2012-07-11), pages 3620 - 3623, XP055715221, ISSN: 1523-7060, DOI: 10.1021/ol301414k
Attorney, Agent or Firm:
YOGO PATENT & TRADE MARK AGENCY LIMITED COMPANY et al. (CN)
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