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Patent Searching and Data


Title:
METHOD FOR PREPARING ANTI-HEART-FAILURE MEDICINE LCZ696
Document Type and Number:
WIPO Patent Application WO/2017/096772
Kind Code:
A1
Abstract:
Disclosed is a method for preparing an anti-heart-failure medicine LCZ696. The preparing method comprises the following steps (formula (I)): in an organic solvent, a sacubitril dicyclohexylamine salt reacts with valsartan under the effect of a sodium hydroxide aqueous solution, and the anti-heart-failure medicine LCZ696 is obtained. The preparing method of the present invention is simple in process and omits the procedures of ion exchange from a sodium salt to a calcium salt and hydrochloric acid dissociation in an existing production process, residues of calcium ions are avoided, and the production efficiency is effectively improved.

Inventors:
ZHU GUORONG (CN)
TU YONGJUN (CN)
XIE WENLONG (CN)
WANG ZHEN (CN)
XU SHAOJUN (CN)
Application Number:
PCT/CN2016/084914
Publication Date:
June 15, 2017
Filing Date:
June 06, 2016
Export Citation:
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Assignee:
ZHEJIANG TIANYU PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D257/04; C07C231/02; C07C233/47
Domestic Patent References:
WO2007056546A12007-05-18
WO2008083967A22008-07-17
WO2008031567A12008-03-20
WO2010034236A12010-04-01
WO2014032627A12014-03-06
WO2007056546A12007-05-18
WO2003059345A12003-07-24
WO2006086456A22006-08-17
WO2007045663A22007-04-26
Foreign References:
CN105348209A2016-02-24
CN105503638A2016-04-20
CN104860894A2015-08-26
Other References:
See also references of EP 3388424A4
Attorney, Agent or Firm:
GRANDALL LAW FIRM (SHANGHAI) (CN)
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