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Title:
METHOD FOR PREPARING DIOSGENIN BY TERNARY TWO-PHASE ALUMINUM CHLORIDE HYDROLYSIS
Document Type and Number:
WIPO Patent Application WO/2021/068991
Kind Code:
A1
Abstract:
A method for preparing diosgenin by ternary two-phase AlCl3 hydrolysis. Dried yam powder is placed into a reaction vessel, and then a ternary, two-phase solution consisting of an aqueous aluminum chloride solution, ethanol, and petroleum ether is added, the components are mixed even, and reacted at 130-180°C for 0.5-3.0 h, the reaction solution is filtered, residue is filtered out, and a petroleum ether layer is separated out for rotary evaporation, and after re-crystallization, diosgenin is obtained. In the present invention, the non-conventional acid and Lewis acid AlCl3 is used for acidolysis in a ternary two-phase system to prepare diosgenin, thus improving diosgenin yield, shortening the extraction period, while also greatly reducing the amount of acid consumed, and more importantly, because concentrated sulfuric acid is not used, environmental pollution is also minimized. The invention therefore has great use potential.

Inventors:
XIE JUN (CN)
ZHANG SHUAISHUAI (CN)
BI GUICAN (CN)
Application Number:
PCT/CN2020/132078
Publication Date:
April 15, 2021
Filing Date:
November 27, 2020
Export Citation:
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Assignee:
UNIV SOUTH CHINA AGRICULT (CN)
International Classes:
C07J71/00
Foreign References:
CN110818770A2020-02-21
CN110643640A2020-01-03
CN108358992A2018-08-03
CN108586412A2018-09-28
CN104478706A2015-04-01
Other References:
YANG, HUAN, YANG KE-DI, CHEN JUN: "The Research on Two-Phase Acid Hydrolysis of Extracting Diosgenin", CHINESE JOURNAL OF MODERN APPLIED PHARMACY, vol. 22, no. 4, 1 January 2005 (2005-01-01), pages 270 - 272, XP055798910, DOI: 10.13748/j.cnki.issn1007-7693.2005.04.002
ROZANSKI A.: "A simplified method of extraction of diosgenin from Dioscorea tubers and its determination by gas-liquid chromatography", ANALYST, ROYAL SOCIETY OF CHEMISTRY, UK, vol. 97, no. 1161, 1 January 1972 (1972-01-01), UK, pages 968 - 972, XP055798911, ISSN: 0003-2654, DOI: 10.1039/an9729700968
Attorney, Agent or Firm:
YOGO PATENT AND TRADEMARK AGENCY LIMITED COMPANY (CN)
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