Title:
METHOD FOR PREPARING HIGH-PURITY CRYSTAL
Document Type and Number:
WIPO Patent Application WO/2022/022367
Kind Code:
A1
Abstract:
Provided is a method for preparing a high-purity crystal. Specifically, the present invention relates to a method for preparing a Lenvatinib mesylate crystal C. The method comprises the following steps: 1) dissolving a Lenvatinib free base in a good solvent to obtain a solution of the Lenvatinib free base; 2) clarifying and filtering the solution of step 1), then adding methanesulfonic acid and a poor solvent I or a solution of methanesulfonic acid in the poor solvent I to the solution, and undergoing a salification reaction to obtain a crude product of Lenvatinib mesylate; and 3) placing the obtained crude product of Lenvatinib mesylate in a poor solvent II and pulping to obtain a Lenvatinib mesylate crystal C, wherein the obtained Lenvatinib mesylate crystal C has a purity of no lower than 99.5% and has no higher than 0.10% of any single impurity and does not exceed more than 0.5% of total impurities. The purity of the Lenvatinib mesylate crystal C prepared according to the above-mentioned preparation method is higher, and the content of impurity A and impurity B is greatly reduced.
Inventors:
HE XUNGUI (CN)
ZHANG HENGBIN (CN)
WANG YUAN (CN)
ZHANG HENGBIN (CN)
WANG YUAN (CN)
Application Number:
PCT/CN2021/107742
Publication Date:
February 03, 2022
Filing Date:
July 22, 2021
Export Citation:
Assignee:
2Y CHEM LTD (CN)
International Classes:
C07D215/48; C07C303/32; C07C309/04
Domestic Patent References:
| WO2019092625A1 | 2019-05-16 |
Foreign References:
| CN111689897A | 2020-09-22 | |||
| CN110256341A | 2019-09-20 | |||
| CN1890220A | 2007-01-03 | |||
| CN106660964A | 2017-05-10 | |||
| CN110818634A | 2020-02-21 | |||
| CN109988112A | 2019-07-09 |
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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