Title:
METHOD FOR PREPARING LACTONE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2019/104850
Kind Code:
A1
Abstract:
Disclosed is a method for preparing a lactone compound, for which a cyclic ketone compound serves as a raw material; in an oxygen-containing atmosphere, a cyclic organic nitroxide free radical serves as a catalyst, and a certain amount of an aldehyde additive is added for a reaction. Disclosed is a preparation method having mild conditions, a high degree of safeness, and a wide range of options for non-metal catalyzed oxidation; the amount of the aldehyde additive used is greatly reduced, the efficiency and range of the aldehyde additive are increased, and the lactone compound can be acquired with a high yield.
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Inventors:
LI HAORAN (CN)
WANG LINGYAO (CN)
YUAN HAORAN (CN)
LIANG CHENG (CN)
LI JINGBO (CN)
WANG LINGYAO (CN)
YUAN HAORAN (CN)
LIANG CHENG (CN)
LI JINGBO (CN)
Application Number:
PCT/CN2018/073177
Publication Date:
June 06, 2019
Filing Date:
January 18, 2018
Export Citation:
Assignee:
UNIV ZHEJIANG (CN)
ZHEJIANG NHU CO LTD (CN)
ZHEJIANG NHU CO LTD (CN)
International Classes:
C07D309/30; C07B41/12; C07D313/04
Foreign References:
| CN103274883A | 2013-09-04 | |||
| US6229023B1 | 2001-05-08 | |||
| CN106967039A | 2017-07-21 |
Other References:
CHEN, SHAOYUN ET AL.: "Promoting the Aerobic Baeyer-Villiger Oxidation of Ketones over Carboxylic Multi-walled Carbon Nanotubes", MOLECULAR CATALYSIS, vol. 438, 7 June 2017 (2017-06-07), pages 152 - 158, XP055617063, ISSN: 2468-8231
CATHY EINHORN ET AL.: "Oxidation of Organic Substrates by Molecular Oxygen Mediated by N-hydroxyphthalimide (NHPI) and Acetaldehyde", CHEM. COMMUN., vol. 5, no. 5, 1 January 1997 (1997-01-01), pages 447 - 448, XP002337957, ISSN: 1359-7345
LUCIO MELONE ET AL.: "Metal-free Aerobic Oxidations Mediated by N-hydroxyphthalimide. A Concise Review", BEILSTEIN J. ORG. CHEM., vol. 9, 2 July 2013 (2013-07-02), pages 1296 - 1310, XP055617069, ISSN: 1860-5397
CATHY EINHORN ET AL.: "Oxidation of Organic Substrates by Molecular Oxygen Mediated by N-hydroxyphthalimide (NHPI) and Acetaldehyde", CHEM. COMMUN., vol. 5, no. 5, 1 January 1997 (1997-01-01), pages 447 - 448, XP002337957, ISSN: 1359-7345
LUCIO MELONE ET AL.: "Metal-free Aerobic Oxidations Mediated by N-hydroxyphthalimide. A Concise Review", BEILSTEIN J. ORG. CHEM., vol. 9, 2 July 2013 (2013-07-02), pages 1296 - 1310, XP055617069, ISSN: 1860-5397
Attorney, Agent or Firm:
HANGZHOU TIANQIN INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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