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Patent Searching and Data


Title:
METHOD FOR PREPARING LEVETIRACETAM
Document Type and Number:
WIPO Patent Application WO/2019/029598
Kind Code:
A1
Abstract:
A preparing method for high-purity levetiracetam, comprising: adjusting the pH of an extracted aqueous layer obtained by dissociating (S)-α-2-oxo-1-pyrrolidineacetic acid (R)- methylbenzylamine salt to 5-9; removing water; adding an organic solvent to form a solution and then performing an esterification reaction with ethyl chloroformate or methylclhlorofonmate; and carrying out an ammonolysis reaction to obtain the levetiracetam. The method simplifies production process, increases yield, reduces or even avoids the used of triethylamine in the esterification process, and reduces the emission of a great amount of three wastes.

Inventors:
CHEN XINLEI (CN)
HU ZHICHENG (CN)
ZHENG LIANG (CN)
DONG PENG (CN)
Application Number:
PCT/CN2018/099533
Publication Date:
February 14, 2019
Filing Date:
August 09, 2018
Export Citation:
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Assignee:
ZHEJIANG HUAHAI PHARM CO LTD (CN)
ZHEJIANG HUAHAI TIANCHENG PHARMACEUTICAL CO LTD (CN)
ZHEJIANG HUAHAI ZHICHENG PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D207/27
Domestic Patent References:
WO2006053441A12006-05-26
Foreign References:
CN107337628A2017-11-10
CN85105301A1987-01-14
CN101333180A2008-12-31
CN101270070A2008-09-24
CN201710681337A2017-08-10
US4696943A1987-09-29
CN101333180A2008-12-31
Other References:
LIU, YUEJIN ET AL.: "Synthesis of Levetiracetam and Its Derivatives", CHINESE JOURNAL OF NEW DRUGS, vol. 16, no. 11, 1 January 2007 (2007-01-01), pages 860 - 864, XP055675010
See also references of EP 3666756A4
Attorney, Agent or Firm:
PATENTSINO IP FIRM (CN)
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