Title:
METHOD FOR PREPARING MESOTRIONE HERBICIDE
Document Type and Number:
WIPO Patent Application WO/2022/012482
Kind Code:
A1
Abstract:
The present invention belongs to the field of organic synthesis, and particularly relates to a method for preparing a mesotrione herbicide. 4-methanesulfonyl-2-nitrobenzoic acid is used as a raw material, and is subjected to a chloroformylation reaction and an esterification reaction to obtain a reaction system containing an enol ester, followed by a rearrangement reaction to prepare mesotrione, that is, a rearrangement catalyst is added into the reaction system containing the enol ester, same is maintained at 0-40ºC and subjected to the rearrangement reaction, so as to obtain mesotrione. According to the method of the present invention, the use of a highly toxic acetone cyanohydrin rearrangement catalyst is avoided, the reaction temperature is appropriate, the reaction time is short, the solvent can be recycled, the total yield of the prepared mesotrione herbicide product can reach 89%, the content is 98%, and the process is safe and environmentally-friendly, creates a small amount of the three wastes, and is suitable for industrial production.
Inventors:
WU HONGFEI (CN)
WU CHANGCHUN (CN)
YU HAIBO (CN)
XU JINGBO (CN)
XU LIBAO (CN)
GUO CHUNXIAO (CN)
CHENG XUEMING (CN)
DONG YAN (CN)
SUN NINGNING (CN)
WU CHANGCHUN (CN)
YU HAIBO (CN)
XU JINGBO (CN)
XU LIBAO (CN)
GUO CHUNXIAO (CN)
CHENG XUEMING (CN)
DONG YAN (CN)
SUN NINGNING (CN)
Application Number:
PCT/CN2021/105865
Publication Date:
January 20, 2022
Filing Date:
July 13, 2021
Export Citation:
Assignee:
SHENYANG SINOCHEM AGROCHEMICALS R & D CO LTD (CN)
JIANGSU YANGNONG CHEMICAL CO (CN)
JIANGSU YANGNONG CHEMICAL CO (CN)
International Classes:
C07C317/24; C07C315/04; C07C317/44
Domestic Patent References:
| WO2009114470A2 | 2009-09-17 |
Foreign References:
| CN108440352A | 2018-08-24 | |||
| CN110818601A | 2020-02-21 | |||
| CN110256308A | 2019-09-20 | |||
| CN101735119A | 2010-06-16 | |||
| CN102895996A | 2013-01-30 | |||
| CN105254543A | 2016-01-20 | |||
| CN109810032A | 2019-05-28 |
Attorney, Agent or Firm:
SHENYANG PATENT & TRADEMARK AGENCY ACADEMIA SINICA (CN)
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