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Patent Searching and Data


Title:
METHOD FOR PREPARING 16β-METHYL STEROID COMPOUND
Document Type and Number:
WIPO Patent Application WO/2018/196883
Kind Code:
A3
Abstract:
Disclosed is a method for preparing 16β-methyl steroid compound, comprising a methylenation reaction and a hydrogenation reduction reaction. Compared to the prior art, the preparation method of the present invention orientedly synthesizes 16β-methyl while avoiding the side reaction which forms 16α-methyl and 15 (16)-alkene, and produces a highly pure product having a HPLC greater than or equal to 96%. Furthermore, the raw excipient used in the present invention is cheap and accessible, the synthesis process is short, and each reaction step is easily implementable with high yield, thereby enabling more economical and safer production.

Inventors:
YANG KUN (CN)
JIANG QINGFENG (CN)
YU CHUANYUN (CN)
HUANG RUILU (CN)
Application Number:
PCT/CN2018/092329
Publication Date:
December 06, 2018
Filing Date:
June 22, 2018
Export Citation:
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Assignee:
GUANGXI WONDER PHARMACEUTICAL CO LTD (CN)
International Classes:
C07J1/00
Foreign References:
CN107021991A2017-08-08
CN103641878A2014-03-19
DE3144049A11983-05-19
US4602008A1986-07-22
Other References:
GONZALEZ, F.B. ET AL.: "Synthesis and Pharmacological Evaluation of 8a-Estradiol Derivatives", STEROIDS, vol. 40, no. 2, 31 August 1982 (1982-08-31), pages 173
WU, LEI ET AL.: "An Improved Method for iynthesizing a-Methylenecycloketones", FINE CHEMICALS, vol. 20, no. 10, 31 October 2003 (2003-10-31), pages 630
Attorney, Agent or Firm:
CHINA TRUER IP (CN)
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