Title:
METHOD FOR PREPARING POTASSIUM ION COMPETITIVE BLOCKER INTERMEDIATE
Document Type and Number:
WIPO Patent Application WO/2022/051979
Kind Code:
A1
Abstract:
A method for synthesizing a key intermediate compound 1 of fexuprazan, which is a potassium ion competitive blocker. The method comprises using 2,4-difluorobenzylamine as a raw material, and sequentially conducting condensation reaction, benzyl protection, ring formation under basic conditions, methylation, deprotection, and the like to obtain a target product. The described method has a yield greater than 50% and has characteristics such as mild reaction conditions, low costs, and the like.
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Inventors:
HUANG ZHINING (CN)
ZHOU ZHANGTAO (CN)
YE WEIPING (CN)
PHILLIS ANDREW TOROA (CN)
MI CHENGGEN (CN)
YANG MANXIN (CN)
ZHOU ZHANGTAO (CN)
YE WEIPING (CN)
PHILLIS ANDREW TOROA (CN)
MI CHENGGEN (CN)
YANG MANXIN (CN)
Application Number:
PCT/CN2020/114470
Publication Date:
March 17, 2022
Filing Date:
September 10, 2020
Export Citation:
Assignee:
GUANGDONG RAFFLES PHARMATECH CO LTD (CN)
International Classes:
C07C227/18; C07D207/36; C07C229/30
Foreign References:
| CN107001263A | 2017-08-01 | |||
| CN108864088A | 2018-11-23 | |||
| CN109867617A | 2019-06-11 | |||
| CN110637009A | 2019-12-31 |
Other References:
YONG‐BIN WANG; QUAN‐HAO WU; ZHI‐PENG ZHOU; SHAO‐HUA XIANG; YUAN CUI; PEIYUAN YU; BIN TAN: "Asymmetric Construction of Axially Chiral 2‐Arylpyrroles by Chirality Transfer of Atropisomeric Alkenes", ANGEWANDTE CHEMIE, vol. 131, no. 38, 12 August 2019 (2019-08-12), DE , pages 13577 - 13581, XP071379322, ISSN: 0044-8249, DOI: 10.1002/ange.201907470
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
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