Title:
METHOD FOR PREPARING (S)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID BY MEANS OF CHEMOENZYMATIC METHOD
Document Type and Number:
WIPO Patent Application WO/2020/107780
Kind Code:
A1
Abstract:
Disclosed is a method for preparing (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid by means of a chemoenzymatic method, comprising: using a racemic 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid as a substrate, stereoselectively catalyzing the R-isomer with a D-amino acid oxidase and generating a corresponding imidic acid by means of oxidative dehydrogenation, wherein the S-isomer is not catalyzed and remains in the reaction system, the imidic acid is made into a racemic substrate under the action of an imidic acid reducing agent, and the R-isomer therein is stereoselectively catalyzed under the action of the D-amino acid oxidase, and thus the S-isomer is prepared. The present method has a reaction yield that can reach 80.6% or more, an ee value of > 99%, and has characteristics such as mild reaction conditions, a strong stereoselectivity, a high reaction efficiency, a high yield, and relatively simple processes.
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Inventors:
WU JIANPING (CN)
JU SHUYUN (CN)
SHI JUNWEI (CN)
YANG LIRONG (CN)
QIAN MINGXIN (CN)
JU SHUYUN (CN)
SHI JUNWEI (CN)
YANG LIRONG (CN)
QIAN MINGXIN (CN)
Application Number:
PCT/CN2019/083840
Publication Date:
June 04, 2020
Filing Date:
April 23, 2019
Export Citation:
Assignee:
TONGLI BIOMEDICAL CO LTD (CN)
UNIV ZHEJIANG (CN)
UNIV ZHEJIANG (CN)
International Classes:
C12P41/00; C07D217/16; C12P13/04
Foreign References:
| CN104557911A | 2015-04-29 | |||
| US20110086396A1 | 2011-04-14 | |||
| CN101194020A | 2008-06-04 |
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT & TRADEMARK AGENCY LTD. (CN)
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