Title:
METHOD FOR PREPARING TRICARBONYL TECHNETIUM-99M INTERMEDIATE
Document Type and Number:
WIPO Patent Application WO/2018/107526
Kind Code:
A1
Abstract:
The invention provides a method for preparing a tricarbonyl technetium-99m intermediate. The method comprises reacting a carbonyl manganese compound used as a carbon monoxide donor with pertechnetate and water to obtain the tricarbonyl technetium-99m intermediate. The method for preparing a tricarbonyl technetium-99m intermediate in an embodiment of the invention can complete the preparation of the intermediate at atmospheric pressure and room temperature. The method is easy to operate, uses easily obtained raw materials, has a high labeling rate, and can be used to prepare various types of tricarbonyl technetium labeled probes.
Inventors:
YANG WENJIANG (CN)
LIU YU (CN)
XUE JINGQUAN (CN)
ZHANG YANHUA (CN)
LIU YU (CN)
XUE JINGQUAN (CN)
ZHANG YANHUA (CN)
Application Number:
PCT/CN2016/112642
Publication Date:
June 21, 2018
Filing Date:
December 28, 2016
Export Citation:
Assignee:
INST HIGH ENERGY PHYSICS CAS (CN)
International Classes:
C01G99/00; C07F13/00
Foreign References:
| CN106745346A | 2017-05-31 | |||
| CN103435655A | 2013-12-11 | |||
| US20090155167A1 | 2009-06-18 |
Other References:
ALBERTO R ET AL.: "A Novel Organometallic Aqua Complex of Technetium for the Labeling of Biomolecules: Synthesis of [99mTc (OH2) 3 (CO) 3]+ from [99mTc04]-in Aqueous Solution and Its Reaction with a Bifunctional Ligand", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 120, no. 31, 24 July 1998 (1998-07-24), pages 7987 - 7988, XP002380957, ISSN: 0002-7863
Attorney, Agent or Firm:
BEIJING INTELLEGAL INTELLECTUAL PROPERTY AGENT LTD. (CN)
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