Title:
METHOD FOR PREPARING URIDINE 5'-DIPHOSPHATE (UDP), SALT THEREOF OR HYDRATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/125819
Kind Code:
A1
Abstract:
A method for preparing uridine 5'-diphosphate (UDP), a salt thereof or a hydrate thereof, of the present invention, comprises the steps of: (step 1) deionizing a salt of uridine 5'-monophosphate (UMP) represented by chemical formula 2a with an acid, thereby preparing UMP represented by chemical formula 2a; (step 2) reacting UMP represented by chemical formula 2a with a tertiary amine, a carbodiimide-based condensing agent and imidazole, thereby preparing uridine-5'-phosphoroimidazolide represented by chemical formula 2b; and (step 3) reacting uridine-5'-phosphoroimidazolide represented by chemical formula 2b with a monophosphorylating agent and a tertiary amine, thereby preparing UDP represented by chemical formula 3a, a salt thereof or a hydrate thereof. Therefore, the present invention can simplify a process by not performing deionization using an ion-exchange resin, and can be commercially and effectively used by performing mass production with a relatively simple process without separate production equipment.
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Inventors:
LEEM HYUNG JOON (KR)
LEE SEUNG UK (KR)
CHO GYEONG HI (KR)
KANG SUNG KWON (KR)
LIM JONG LAE (KR)
LEE SEUNG UK (KR)
CHO GYEONG HI (KR)
KANG SUNG KWON (KR)
LIM JONG LAE (KR)
Application Number:
PCT/KR2020/018514
Publication Date:
June 24, 2021
Filing Date:
December 17, 2020
Export Citation:
Assignee:
CHONG KUN DANG PHARMACEUTICAL CORP (KR)
International Classes:
C07H19/10
Foreign References:
| KR20180091672A | 2018-08-16 | |||
| JP2001513568A | 2001-09-04 | |||
| US20040267005A1 | 2004-12-30 |
Other References:
ANILKUMAR R. KORE , GAURANG PARMAR: "Convenient Synthesis of Nucleoside‐5′‐Diphosphates from the Corresponding Ribonucleoside‐5′‐phosphoroimidazole", SYNTHETIC COMMUNICATIONS, vol. 36, no. 22, 1 January 2006 (2006-01-01), pages 3393 - 3399, XP055822046, ISSN: 0039-7911, DOI: 10.1080/00397910600941448
PETER TREMMEL, HELMUT GRIESSER, ULRICH E. STEINER, CLEMENS RICHERT: "How Small Heterocycles Make a Reaction Network of Amino Acids and Nucleotides Efficient in Water", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 58, no. 37, 9 August 2019 (2019-08-09), pages 13087 - 13092, XP055822058, ISSN: 1433-7851, DOI: 10.1002/ange.201905427
QI SUN , JOCELYN P EDATHIL , RUNZHI WU , ERIC DS SMIDANSKY , CRAIG E CAMERON , BLAKE R PETERSON: "One-pot synthesis of nucleoside 5'-triphosphates from nucleoside 5'-H-phosphonates", ORGANIC LETTERS, vol. 10, no. 9, 1 January 2008 (2008-01-01), pages 1703 - 1706, XP002598618, ISSN: 1523-7060, DOI: 10.1021/ol8003029
PETER TREMMEL, HELMUT GRIESSER, ULRICH E. STEINER, CLEMENS RICHERT: "How Small Heterocycles Make a Reaction Network of Amino Acids and Nucleotides Efficient in Water", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 58, no. 37, 9 August 2019 (2019-08-09), pages 13087 - 13092, XP055822058, ISSN: 1433-7851, DOI: 10.1002/ange.201905427
QI SUN , JOCELYN P EDATHIL , RUNZHI WU , ERIC DS SMIDANSKY , CRAIG E CAMERON , BLAKE R PETERSON: "One-pot synthesis of nucleoside 5'-triphosphates from nucleoside 5'-H-phosphonates", ORGANIC LETTERS, vol. 10, no. 9, 1 January 2008 (2008-01-01), pages 1703 - 1706, XP002598618, ISSN: 1523-7060, DOI: 10.1021/ol8003029
Attorney, Agent or Firm:
AHN, So Young (KR)
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